{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T20:02:32Z","timestamp":1784404952229,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/14942\u20101"],"award-info":[{"award-number":["2020\/14942\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prebiotic therapy is a promising approach for managing periodontitis due to its potential benefits in modulating the microbiome and the immune response. This study aimed to evaluate the effects of the prebiotic (PREB) polydextrose (PDX) on the development of experimental periodontitis (EP) in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 44 male adult rats (\n                      <jats:italic>Rattus norvegicus, albinus<\/jats:italic>\n                      , Wistar) were randomly allocated into groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011) C (control), PREB, EP, and EP\/PREB. The PREB and EP\/PREB groups received 2\u00a0g of PDX\/day in the drinking water for 44 days. The EP and EP\/PREB groups received cotton ligatures around mandibular first molars (M1) for 14 days. Microtomographic, histopathological, and immunohistochemical analyses of periodontal and intestinal tissues were performed. Data were analyzed statistically (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The EP\/PREB group showed less alveolar bone destruction than the EP group. The EP\/PREB group exhibited higher expressions of IL\u201010 and a lower number of TRAP (tartrate\u2010resistant acid phosphatase)\u2010positive cells than the EP group in periodontal tissues. The EP\/PREB group had increased villus heights in the duodenum and ileum, increased crypt depths in the duodenum, and higher expressions of occludin in all intestinal portions, claudin\u20101 in the jejunum, IL\u201010 in the duodenum, and lower expressions of IL\u20101\u03b2 in the jejunum compared with the EP group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Polydextrose exerted a protective effect against alveolar bone resorption and favorably modulated both local and systemic immune\u2010inflammatory response in rats with experimental periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Prebiotic therapy has emerged as a promising approach for treating periodontitis, an immunoinflammatory disease associated with a dysbiotic biofilm that leads to the loss of the supporting structures of the teeth. This is because prebiotics can positively influence the balance of bacteria in the body and the immune system's response. However, current understanding of its potential effects and mechanisms of action remains limited in periodontal therapy. The effects of the prebiotic polydextrose (PDX) on periodontal tissues remain unknown. The results of the present study show that the prebiotic PDX can minimize alveolar bone loss and improve bone microarchitecture through modulation of the immune\u2010inflammatory response in both intestinal and periodontal tissues of rats with experimental periodontitis. Our findings suggest that the prebiotic PDX may represent a beneficial adjunctive strategy for managing periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70095","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:43:45Z","timestamp":1771505025000},"page":"1529-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunological and periodontal benefits of prebiotic polydextrose in rats with induced periodontitis"],"prefix":"10.1002","volume":"97","author":[{"given":"Raquel de S. F.","family":"Nassar","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina P.","family":"Hernandes","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Z.","family":"Gianduzzo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa de P. S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio L. S.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses, School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University \u2013 UNESP, Ara\u00e7atuba School of Dentistry  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora S. F.","family":"S\u00e1vio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel R.","family":"Messora","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto School of Dentistry University of Sao Paulo \u2013 USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-3983","authenticated-orcid":false,"given":"Fl\u00e1via A. 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