{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:45Z","timestamp":1789456065020,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this systematic review is to evaluate the efficacy of cell\u2010based therapies and biologically enhanced scaffolds for peri\u2010implant soft tissue regeneration, including the increase in soft tissue thickness (STT) and\/or keratinized mucosa (KM) augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted in Ovid MEDLINE, EMBASE, and Dentistry and Oral Sciences Source until August 2025. A focused question was developed: \u201cIn patients with soft tissue defects requiring soft tissue augmentation procedures prior to, at the time of implant placement or after it, what is the efficacy of combining cell therapy and\/or biological treatments with a soft tissue scaffold compared to the use a soft tissue scaffold without cells and\/or biologics, or no scaffold, on the increase of STT and\/or KM in clinical trials or prospective case series?\u201d. Post\u2010operative morbidity, interproximal bone level changes, clinical peri\u2010implant outcomes or patient\u2010reported outcome measures (PROMs) were collected. Risk of bias was assessed using RoB 2.0, ROBINS\u2010I and the National Institutes of Health (NIH) Study Quality Assessment Tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten publications were included (six randomized clinical trials [RCTs] and four prospective case series). The use of free gingival grafts (FGGs) lead to significantly greater KM augmentation when compared with platelet\u2010rich fibrin (PRF) membranes (weighted mean difference [WMD]\u00a0=\u00a0\u22122.0; 95% confidence interval [CI]: \u22123.3, \u22120.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) although PRF membranes significantly increased the amount of KM when compared to no scaffold\/graft (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02; WMD\u00a0=\u00a01.1\u00a0mm; 95% CI: 0.2, 2.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) and seem to increase also STT. Available data on other biologics (e.g., recombinant human platelet\u2010derived growth factor BB [rhPDGF\u2010BB]) are scarce. No studies evaluating cell therapies were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRF membranes are effective in increasing the KM and STT around dental implants, even if KM augmentation by means of autogenous grafts lead to superior outcomes. There is a lack of evidence on cell\u2010based therapies or other biologics for their use in soft tissue regeneration around dental implants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70107","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:19:35Z","timestamp":1789453175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of cells and\/or biologics combined with scaffolds for soft tissue regeneration around dental implants"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-8529","authenticated-orcid":false,"given":"Eduardo","family":"Montero","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad Complutense de Madrid  Madrid 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-2420","authenticated-orcid":false,"given":"George A.","family":"Mandelaris","sequence":"additional","affiliation":[{"name":"Private practice  Chicago Illinois 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