{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:05:06Z","timestamp":1791381906836,"version":"4.3.3"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health\u2013related quality of life (OHRQoL) in adults with systemic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical periodontal examination) and OHRQoL (validated instrument). Random\u2010effects models were applied in the meta\u2010analyses, and the Newcastle\u2010Ottawa Scale (NOS) was used for quality assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen studies were included, with 94.1% using the OHIP\u201014 instrument. Only one study was rated as high quality. Meta\u2010analysis showed a small and significant association between periodontitis and impaired OHRQoL (SMD: 0.31; 95% CI: 0.03\u20130.59). Individuals with periodontitis had higher OHIP\u201014 scores than the comparison group (MD: 2.29; 95% CI: 0.24\u20134.33). Studies using the 2017 periodontitis classification yielded significantly higher estimates than those using earlier criteria. Furthermore, a strong negative impact of periodontitis on OHRQoL was observed among individuals with psoriasis, whereas no significant association was identified for other systemic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Periodontitis has a small negative impact on OHRQoL in patients with comorbidities. The type of systemic condition and the periodontitis diagnostic criteria influence this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Periodontitis negatively impacts oral health\u2013related quality of life across different populations. However, this impact may appear smaller in individuals with certain systemic conditions, as additional health challenges can overshadow the perceived effects of periodontitis on daily life. Our systematic review found a small negative impairment of OHRQoL associated with periodontitis in patients with comorbidities, with the magnitude of this association influenced by the type of systemic condition and the diagnostic criteria used to define periodontitis. Further high\u2010quality studies are needed to strengthen the current evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70130","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:30:02Z","timestamp":1776580202000},"page":"1990-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between periodontitis and oral health\u2013related quality of life in patients with systemic conditions: A meta\u2010analysis"],"prefix":"10.1002","volume":"97","author":[{"given":"Rafael Vargas","family":"Bortolaso","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Stomatology, Emphasis on Periodontics Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catiusse Crestani","family":"Del' Agnese","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Stomatology, Emphasis on Periodontics Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-5687","authenticated-orcid":false,"given":"Leandro Machado","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Stomatology, Emphasis on Periodontics Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Miguez","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics and Dental Hygiene, Adams School of Dentistry The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-7961","authenticated-orcid":false,"given":"Fabricio Batistin","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Stomatology, Emphasis on Periodontics Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Pippi","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Stomatology, Emphasis on Periodontics Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752\u20107325.2002.tb03415.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399918"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13337"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12447"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12200"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12305"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12805"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12451"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102\u2010311x2007000300022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13233"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12938"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58050584"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12344"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102068\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010018\u20102375\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12625"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102298\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001275\u20104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a44685"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14074"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12689"},{"key":"e_1_2_10_26_1","unstructured":"WellsG SheaB O'ConnellD et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses 2011. 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