{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:05:07Z","timestamp":1791381907759,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n More evidence is needed to assess the association between periodontitis and Oral Health\u2010Related Quality of Life (OHRQoL) quantitatively. We hypothesized that periodontal inflammation is correlated with a worsening in quality of life and aimed to test this in this study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 1307 participants in King's Oral Biobank answered the Oral Health Impact Profile\u201014 (OHIP\u201014) questionnaire (measurement of OHRQoL) during a dental visit. The associations between periodontal inflammation, measured as periodontal inflamed surface area (PISA) and bleeding on probing (BOP), periodontal conditions (diagnosis\/staging), and OHIP\u201014 scores across all seven domains (functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap) were investigated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The PISA exhibited weak linear correlations with the overall OHIP\u201014 score (Pearson correlation coefficient\n r<\/jats:italic>\n \u00a0=\u00a00.06,\n p<\/jats:italic>\n \u00a0=\u00a00.037), particularly with the \u201cphysical pain\u201d subdomain (\n r<\/jats:italic>\n \u00a0=\u00a00.12,\n p<\/jats:italic>\n \u00a0<\u00a00.001). BOP was associated with the OHIP overall score (\n r<\/jats:italic>\n \u00a0=\u00a00.08,\n p<\/jats:italic>\n \u00a0=\u00a00.022). In addition, stage IV periodontitis was associated with higher OHIP\u201014 total scores and with multiple subdomains, including physical pain, physical disability and psychological discomfort.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Inflammation indices such as BOP and PISA are associated with worse OHRQoL. In addition, the complex clinical features of stage IV periodontitis may worsen OHRQoL, especially in relation to physical pain, physical disability and psychological discomfort.<\/jats:p>\n <\/jats:sec>\n \n Plain Language Summary<\/jats:title>\n This study shows that having more advanced gum disease (stage IV) and gum inflammation may worsen quality of life.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jper.70165","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:25:04Z","timestamp":1786080304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between periodontal inflammation and OHIP\u201014 scores: A cross\u2010sectional study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3611-1674","authenticated-orcid":false,"given":"Yanwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Centre of Oral, Clinical and Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koula","family":"Asimakopoulou","sequence":"additional","affiliation":[{"name":"Faculty of Health Science and Technology Oxford Brookes University Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Redman","sequence":"additional","affiliation":[{"name":"Lewisham London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Lomax","sequence":"additional","affiliation":[{"name":"Oral Healthcare HALEON Weybridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Kang","sequence":"additional","affiliation":[{"name":"Centre of Oral, Clinical and Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences King's College London London 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