{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:09:36Z","timestamp":1783926576197,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This prospective study aimed to assess the clinical outcomes and patient\u2010related outcome measures (PROMs) of open flap debridement (OFD) alone versus open flap debridement with leukocyte\u2013platelet\u2010rich fibrin (L\u2010PRF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one patients were enrolled into a split\u2010mouth randomized clinical trial. One side of the arch underwent OFD; the contralateral side of the same arch underwent the same OFD procedure with L\u2010PRF placed across the alveolar bone and root surfaces underneath the buccal and lingual\/palatal flap. Clinical parameters for probing depth (PD) and relative gingival recession (RGR) were recorded at six sites per tooth using a thermoplastic stent at baseline (immediately before surgery), 3 months, and 6 months. Bleeding on probing (BOP) and plaque scores were recorded at six sites per tooth throughout the study duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The greatest reductions in PD were observed for sites\u00a0\u2265\u00a07\u00a0mm. Mean PD in the control group decreased from 7.38\u00a0mm at baseline to 3.15\u00a0mm at 3 months, with a subsequent increase to 4.00\u00a0mm at 6 months. In contrast, the test group demonstrated a sustained reduction from 7.75\u00a0mm at baseline to 3.25\u00a0mm at 3 months and 3.19\u00a0mm at 6 months. In moderate sites (4\u20136\u00a0mm), both groups demonstrated substantial PD reduction. Moderate subgroup mean PD decreased from 4.62\u00a0mm to 3.09\u00a0mm in the control group and from 4.76\u00a0mm to 3.19\u00a0mm in the test group at the 6\u2010month timepoint. Relative recession and relative attachment level revealed no significant differences between the groups across all PDs. PROMs data showed that, although test group patients reported more swelling and pain early after surgery, they used less analgesics than the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the findings from this randomized clinical study, L\u2010PRF was found to have improved, sustained PD reduction in deep periodontal pockets compared to OFD alone. L\u2010PRF was not found to have a significant impact on PROMs or soft tissue healing compared to OFD alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov Identifier<\/jats:title>\n                    <jats:p>NCT06296498<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>In this split mouth, same arch clinical study, 21 patients were randomized into two study groups: open flap debridement (OFD) and OFD plus leukocyte\u2013platelet\u2010rich fibrin (L\u2010PRF). Clinical parameters were recorded at baseline, 3 months, and 6 months after intervention, while healing and patient\u2010reported outcome measures (PROMs) were evaluated 2 and 4 weeks after surgery.<\/jats:p>\n                    <jats:p>In sites\u00a0\u2265\u00a07\u00a0mm baseline PD, OFD plus L\u2010PRF was associated with greater probing depth (PD) reduction and attachment level (AL) gain than control OFD alone, with similar gingival recession in both groups. Overall test group PD decrease was 4.44\u00a0mm, resulting in 1.05\u00a0mm more PD decrease in test sites than control. L\u2010PRF effect was sustained with PD values in test sites reduced to 3.25\u00a0mm and 3.19\u00a0mm at 3 and 6 months, respectively (from 7.75\u00a0mm at baseline). The addition of L\u2010PRF did not provide benefits in PROMs and soft tissue healing compared to sites treated with OFD alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70166","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:37:19Z","timestamp":1783924639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of leukocyte\u2013platelet\u2010rich fibrin in periodontal surgery on clinical parameters and patient\u2010related outcome measures: A randomized, controlled, clinical study"],"prefix":"10.1002","author":[{"given":"Jackson S.","family":"Sides","sequence":"first","affiliation":[{"name":"Department of Periodontics UT Health San Antonio School of Dentistry  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archontia","family":"Palaiologou","sequence":"additional","affiliation":[{"name":"Department of Periodontics UT Health San Antonio School of Dentistry  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-9905","authenticated-orcid":false,"given":"Brian L.","family":"Mealey","sequence":"additional","affiliation":[{"name":"Department of Periodontics UT Health San Antonio School of Dentistry  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J.","family":"Haney","sequence":"additional","affiliation":[{"name":"Department of Periodontics UT Health San Antonio School of Dentistry  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Font","sequence":"additional","affiliation":[{"name":"Private practice  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-9095","authenticated-orcid":false,"given":"Charles 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