{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:51:51Z","timestamp":1791993111484,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Periodontology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dental implants are a long\u2010term and reliable solution to replace missing dentition, but subject to different patient\u2010related and biological changes that could alter its success. Xerostomia, or the alteration of the normal salivary flow, can impair oral function and potentially affect the success of any treatment, including implant outcomes. The purpose of this study is to study the association between xerostomia and peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted using records of patients who received dental implants between 2010 and 2023 at the University of Michigan School of Dentistry. The patients were divided into two groups: the xerostomia group and the non\u2010xerostomia group. Implant level assessment included the presence of peri\u2010implantitis and marginal bone loss, restoration type, cement\u2010retained or screw retained, and the depth of restoration margin. Patient\u2010level assessment included sex, age, smoking history, medical conditions, and maintenance visit frequency. Univariable and multivariable mixed\u2010effects logistic regression analyses were performed to assess the association between peri\u2010implantitis and patient\u2010level and other implant\u2010related variables. Odds ratios with 95% confidence intervals were reported, and statistical significance was defined as\n                      <jats:italic>p\u00a0&lt;<\/jats:italic>\n                      \u00a00.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 173 patients were included, with 46 patients reporting xerostomia. The results showed no independent association between xerostomia and peri\u2010implantitis in either univariable or multivariable analyzes. The history of periodontitis and cement\u2010retained restorations were significant predictors for peri\u2010implantitis. Age was significant in univariable analysis but lost significance in the adjusted model. The frequency of maintenance visits was associated with peri\u2010implantitis in univariable analysis but lost significance in multivariable analysis. Sex, smoking, and diabetes mellitus were not significantly associated with peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Xerostomia alone does not increase the risk of peri\u2010implantitis. A history of periodontitis, the use of cement\u2010retained prosthesis, and longer follow\u2010up duration after prosthetic loading were associated with unfavorable implant outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jper.70192","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:43:27Z","timestamp":1791992607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between xerostomia and peri\u2010implant health: A retrospective cohort study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2112-2804","authenticated-orcid":false,"given":"Shahad","family":"Alhazmi","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-629X","authenticated-orcid":false,"given":"Sahar","family":"Baniameri","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8362-3208","authenticated-orcid":false,"given":"Parham","family":"Hazrati","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0371-303X","authenticated-orcid":false,"given":"Yousef","family":"Amrou","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9726-7217","authenticated-orcid":false,"given":"Fatemeh","family":"SamavatiJame","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Periodontology Nova Southeastern University, School of Dentistry  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-7317","authenticated-orcid":false,"given":"Muhammad H. 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