{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:35:39Z","timestamp":1792607739488,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to assess long\u2010term health\u2010related quality of life (HRQoL) in children and adolescents with coeliac disease (CD), and their parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We re\u2010evaluated prospectively the HRQoL and clinical characteristics of 80 families, assessed 5 years earlier, using a disease\u2010specific questionnaire, the CD Dutch Questionnaire (CDDUX), and a generic questionnaire, the Paediatric Quality of Life Inventory (PedsQL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a 10\u2010year follow\u2010up, there was no significant change in the total CDDUX and PedsQL scores in children and their parents when compared to the evaluation conducted 5 years earlier. The total CDDUX score reflected a neutral QoL, while for the generic PedsQL was good\u2010very good. The only significant decrease after 5 years was the PedsQL subdomain <jats:italic>Emotional functioning<\/jats:italic>. Patients who admitted voluntarily eating gluten reported lower score in CDDUX <jats:italic>Diet<\/jats:italic>. Lower scores in subdomain \u201c<jats:italic>Physical functioning\u201d<\/jats:italic> (PedsQL) were reported in patients with positivity of TTG or associated diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CDDUX score indicated a consistently stable and neutral QoL perception among coeliac patients and caregivers, even after 10\u2010year postdiagnosis, suggesting minimal fluctuations in the impact of CD on disease\u2010specific health domains over time. Furthermore, the consistently good PedsQL score could be a reflection of the resilience of coeliac families in coping with this chronic condition. Gluten\u2010free diet compliance was confirmed to be determinant of HRQoL in the long term. The study confirms the importance of extending surveillance on these patients, possibly using different questionnaires, to assess QoL from different perspectives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12049","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:05:30Z","timestamp":1702721130000},"page":"105-112","source":"Crossref","is-referenced-by-count":13,"title":["Health\u2010related quality of life in children with coeliac disease and in their families: A long\u2010term follow\u2010up study"],"prefix":"10.1002","volume":"78","author":[{"given":"Marco","family":"Crocco","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genova Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Malerba","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genova Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Calvi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Zampatti","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) University of Genova Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gandullia","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Madeo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tappino","sequence":"additional","affiliation":[{"name":"Laboratory for the Study of Inborn Errors of Metabolism (LABSIEM) IRCCS Istituto Giannina Gaslini Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Proietti","sequence":"additional","affiliation":[{"name":"Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana Rome Italy"},{"name":"Department of Human Sciences and Quality of Life Promotion San Raffaele University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonassi","sequence":"additional","affiliation":[{"name":"Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana Rome Italy"},{"name":"Department of Human Sciences and Quality of Life Promotion San Raffaele University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1113994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2022-000914"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020485"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01494-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614560786"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113467"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030559"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31815ef87d"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-204"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"19","article-title":"Implementation 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