{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:56:37Z","timestamp":1790218597829,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical, endoscopic, histologic, and treatment outcomes of <jats:italic>Helicobacter heilmannii<\/jats:italic> (<jats:italic>H. heilmannii<\/jats:italic>) associated gastritis in children in the New England region of the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of children (1\u201318 years) with <jats:italic>H. heilmannii<\/jats:italic> identified on gastric mucosal biopsies from two pediatric centers over a 21\u2010year period, January 2000\u2013December 2021. Cases were identified by querying pathology databases at each institution. Demographic and clinical data were obtained from the medical record. Endoscopic and histologic findings were extracted from endoscopy and pathology reports, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight children were diagnosed with <jats:italic>H. heilmannii<\/jats:italic>\u2010associated gastritis during the study period. The mean age at diagnosis was 10.1\u2009\u00b1\u20095.3 years, and 25\/38 (66%) cases were male. Abdominal pain (32%) and nausea with or without vomiting (26%) were the most common symptoms. Thirty\u2010two children (84%) had endoscopic findings including gastric nodularity (55%) and erythema (26%). All children had histologic signs of chronic gastritis, including those with normal endoscopic exams. Antibiotic regimens used for treating <jats:italic>Helicobacter pylori<\/jats:italic> were frequently prescribed. Of the 17 children who underwent a follow\u2010up endoscopy (range 2\u201368 months), 15 (88%) did not have <jats:italic>H. heilmannii<\/jats:italic> identified on gastric biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>H. heilmannii<\/jats:italic> was an infrequent but potential cause of epigastric abdominal pain and nausea in our cohort of New England children. While morphologically distinct from <jats:italic>H. pylori<\/jats:italic>, the bacteria can result in similar endoscopic and histologic findings of nodularity and chronic gastritis, respectively. The rate of eradication, as assessed by histology following treatment with <jats:italic>H. pylori<\/jats:italic> therapies, was below the 90% recommended goal for antimicrobial therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12058","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T07:58:44Z","timestamp":1702713524000},"page":"204-210","source":"Crossref","is-referenced-by-count":6,"title":["Clinical presentation and outcomes of <i>Helicobacter heilmannii<\/i> gastritis in children in the New England region of the United States"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-5785","authenticated-orcid":false,"given":"Denis","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina 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