{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:57:15Z","timestamp":1783630635009,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Radiological intervention (RI) is the preferred treatment in children with Budd\u2010Chiari syndrome (BCS). We studied the comparative long\u2010term outcome of BCS children, with and without RI and utility of liver and splenic stiffness measurement (LSM, SSM) by 2\u2010dimensional shear wave elastography (2D\u2010SWE) in assessing response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty children (40 boys, median age 10.5 [6.5\u201315.25] years) with BCS (29 newly diagnosed, 31 follow\u2010up) were evaluated. LSM and SSM by 2D\u2010SWE and vascular patency were monitored pre\u2010 and postprocedure (\u2265\u20096 months postprocedure) in those undergoing RI. Medical therapy without anticoagulation and monitoring was done in subjects without RI. The RI and no\u2010RI groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ascites (54,90%), hepatomegaly (56,93%) and prominent abdominal\u2010veins (42,70%), were the commonest features. The majority (46,78%) had isolated hepatic vein block. 44 (73%) cases underwent RI, while 16 (27%) were managed conservatively. Both groups were similar at baseline. Post\u2010RI subjects showed significant improvement in clinical findings, liver functions and portal hypertension. LSM [33 (32\u201334.5) to 19.2 (18\u201320.67) kPa] and SSM [54.5 (52.3\u201357.6) to 28.9 (27.6\u201330.25) kPa] showed a significant decline from baseline value over a follow\u2010up of 12 (6\u201313) months. Gradual reduction occurred in the LSM and SSM over 1\u20135 years, with near\u2010normal LSM [10.2 (9.2\u201311.5) kPa] and SSM [22.3 (20.5\u201324.3) kPa] values in patients (n\u201016) with &gt;\u20095 years follow\u2010up. Patients without RI showed worsening in LSM and SSM. Hepatopulmonary syndrome and hepatocellular carcinoma developed in 4 (8%) and 1 (1.7%) cases respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RI leads to clinical recovery and reduction with near normalization of LSM and SSM over long\u2010term follow\u2010up in children with BCS. 2D\u2010SWE is a promising tool to monitor outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12067","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T12:55:16Z","timestamp":1702731316000},"page":"17-26","source":"Crossref","is-referenced-by-count":4,"title":["Budd\u2010Chiari syndrome in children: Radiological intervention and role of shear wave elastography in monitoring response"],"prefix":"10.1002","volume":"78","author":[{"given":"Arghya","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow 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