{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:24:48Z","timestamp":1790749488883,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Food protein\u2010induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin (IgE)\u2010mediated food hypersensitivity and the exact mechanisms that cause FPIAP are unknown. Chemokines play crucial roles in the development of allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine serum levels of a group of chemokines in infants with FPIAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 67 infants with FPIAP and 65 healthy infants, we measured serum levels of mucosa\u2010associated epithelial chemokine (MEC\/CCL28), thymus\u2010expressed chemokine (TECK\/CCL25), CX3CL1 and macrophage inflammatory protein (MIP)\u20103a\/CCL20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants with FPIAP had a lower median value of MIP3a\/CCL20 than healthy infants [0.7 (0\u2013222) vs. 4 (0\u2013249) pg\/mL, respectively] (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Infants with MIP3a\/CCL20 levels \u22640.95\u2009pg\/mL have 13.93 times more risk of developing FPIAP than infants with MIP3a\/CCL20 levels &gt;0.95\u2009pg\/mL. Serum MEC\/CCL28, TECK\/CCL25, and CX3CL1 levels were similar between the infants with FPIAP and the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MIP3a\/CCL20 serum levels were reduced in infants with FPIAP compared with healthy controls. Whether this finding has a role in pathogenesis remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12069","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:06:43Z","timestamp":1702721203000},"page":"211-216","source":"Crossref","is-referenced-by-count":4,"title":["Food protein\u2010induced allergic proctocolitis in infants is associated with low serum levels of macrophage inflammatory protein\u20103a"],"prefix":"10.1002","volume":"78","author":[{"given":"Burcu Tahire","family":"Koksal","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeren","family":"Bar\u0131s","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Eskisehir Osmangazi University Faculty of Medicine Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Sencelikel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Ankara Medipol University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Ozcay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem Y\u0131lmaz","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2000.tb02682.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11236.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13089"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800196"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00389-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.039"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.02.030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1860"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.041"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02870.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.98"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03639.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.09.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441471"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103147"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80201-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.12.018"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060817"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00805"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq478"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102846"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12431"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12218"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T06:54:06Z","timestamp":1723445646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jpn3.12069"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12069","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,11]]}}}