{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:00:51Z","timestamp":1792616451440,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Data driven strategies for acute pancreatitis (AP) in pediatrics are limited; adult data suggests lactated ringers (LR) compared to normal saline (NS) resulted in favorable outcomes, but has not been studied in pediatrics. Our objective was to evaluate the efficacy of LR during the first 48\u2009h of an AP episode compared with NS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      A multisite randomized controlled clinical trial, from 2015 to 2020 (Clinical\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Trials.gov\">Trials.gov<\/jats:ext-link>\n                      NCT03242473). Patients were randomized to exclusively LR or NS for the first 48\u2009h. Primary outcomes were serial C\u2010reactive protein (CRP) values. Secondary outcomes included other lab\u00a0values, time to feeds, length of stay (LOS), systemic inflammatory response syndrome (SIRS) development, and progression to severe AP (SAP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 76 patients (38 LR, 38 NS). CRP at 24 and 48\u2009h were not significantly different between LR or NS group. Additionally, there were no differences in trends of BUN, amylase, lipase, SIRS status, or SAP development between the LR and NS group at 24 and 48\u2009h. A higher proportion of LR patients (32%, 12\/38) were discharged before 48\u2009h compared to NS (13%, 5\/38). The LR group had a significantly higher rate of discharge within the first 72\u2009h compared to the NS group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of LR was associated with a faster rate of discharge during the intervention period and in the first 72\u2009h, but no other differences compared to NS. This reduction in length of hospitalization has significant implications for patients and healthcare costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.12082","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T05:10:30Z","timestamp":1702703430000},"page":"360-368","source":"Crossref","is-referenced-by-count":8,"title":["Faster discharge with lactated ringers than normal saline in first 72\u2009h\u00a0of acute pancreatitis: A multicenter randomized trial"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0559-3779","authenticated-orcid":false,"given":"Peter R.","family":"Farrell","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica W.","family":"DesPain","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine The Children's Hospital of San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Farmer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Hospital Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Greenfield","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston Texas USA"},{"name":"Division of Emergency Medicine Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Hornung","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Children's National Health System Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Pearman","sequence":"additional","affiliation":[{"name":"Alabama College of Osteopathic Medicine Dothan Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beemnet","family":"Neway","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NewYork Presbyterian\u2010Weill Cornell Medical Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Heubi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Children's National Health System Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Ammoury","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Eastern Virginia Medical School Norfolk Virginia USA"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Hospital of the King's Daughters, Children's Specialty Group Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu\u2010El\u2010Haija","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Division of Gastroenterology, 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