{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:57Z","timestamp":1792084137165,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various studies have shown that oropharyngeal colostrum application (OPCA) is beneficial to preterm neonates. We performed a systematic review and meta\u2010analysis to assess whether OPCA reduces the incidence of culture\u2010proven neonatal sepsis in preterm neonates. Randomized controlled trials comparing OPCA with placebo or standard care in preterm neonates were included. Medline, Embase, Web of Science, Cumulated Index to Nursing and Allied Health Literature, Scopus, and CENTRAL were searched for studies published up to June 15, 2023. We used the Cochrane Risk of Bias tool, version 2, for risk of bias assessment, the random\u2010effects model (RevMan 5.4) for meta\u2010analysis, and Gradepro software for assessing the certainty of evidence. Twenty\u2010one studies involving 2393 participants were included in this meta\u2010analysis. Four studies had a low risk of bias, whereas seven had a high risk. Oropharyngeal colostrum significantly reduced the incidence of culture\u2010proven sepsis (18 studies, 1990 neonates, risk ratio [RR]: 0.78, 95% confidence interval [95% CI]: 0.65, 0.94), mortality (18 studies, 2117 neonates, RR: 0.73, 95% CI: 0.59, 0.90), necrotizing enterocolitis (NEC) (17 studies, 1692 neonates, RR: 0.59, 95% CI: 0.43, 0.82), feeding intolerance episodes (four studies, 445 neonates, RR: 0.59, 95% CI: 0.38, 0.92), and the time to full enteral feeding (19 studies, 2142 neonates, mean difference: \u22122 to 21 days, 95% CI: \u22123.44, \u22120.99 days). There was no reduction in intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, ventilator\u2010associated pneumonia, neurodevelopmental abnormalities, hospital stay duration, time to full oral feeding, weight at discharge, pneumonia, and duration of antibiotic therapy. The certainty of the evidence was high for the outcomes of culture\u2010positive sepsis and mortality, moderate for NEC, low for time to full enteral feeding, and very low for feeding intolerance. OPCA reduces culture\u2010positive sepsis and mortality (high certainty), NEC (moderate certainty), and time to full enteral feeding (low certainty) in preterm neonates. However, scarcity of data from extremely premature infants limits the generalizability of these results to this population.<\/jats:p>","DOI":"10.1002\/jpn3.12085","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:10:32Z","timestamp":1702721432000},"page":"471-487","source":"Crossref","is-referenced-by-count":16,"title":["Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-4453","authenticated-orcid":false,"given":"Rajendra Prasad","family":"Anne","sequence":"first","affiliation":[{"name":"Department of Neonatology, Kasturba Medical College Manipal Academy of Higher Education (MAHE) Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jogender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Advanced Pediatric Center Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Advanced Pediatric Center Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30063-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497781"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215683"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2022-0131"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.133652"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu3040442"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2021.0173"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000691"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0854-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06243-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20231478"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2021.0184"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.891491"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-03982-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-022-01589-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_20_1","unstructured":"Anon. 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