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However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients with EA\u00a0and its complications. We, therefore, performed a systematic review including all reports on the subject from 1980 to 2022. We conducted meta\u2010analysis of the pooled proportion of PPI\u2014and no PPI groups using random effect model, meta\u2010regression, and estimate heterogeneity by heterogeneity index <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>. Thirty\u2010eight reports on the topic met the criteria selection, representing a cumulative 6044 patients with EA. Prophylactic PPI prescription during the first year of life does not appear to prevent GERD persistence at follow\u2010up and is not associated with a significantly reduced rate of antireflux surgical procedures (ARP). PPIs improve peptic esophagitis and induce remission of eosinophilic esophagitis at a rate of 50%. Their effect on other GERD outcomes is uncertain. Evidence suggests that PPIs do not prevent anastomotic stricture, Barrett's esophagus, or respiratory complications. PPI use in EA can improve peptic and eosinophilic esophagitis but is ineffective on the other EA complications. Side effects of PPIs in EA are almost unknown.<\/jats:p>","DOI":"10.1002\/jpn3.12115","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T02:13:56Z","timestamp":1706062436000},"page":"457-470","source":"Crossref","is-referenced-by-count":15,"title":["Proton pump inhibitors in esophageal atresia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"78","author":[{"given":"Georges","family":"Dimitrov","sequence":"first","affiliation":[{"name":"Unit of Pediatric Surgery, Unit of Pediatrics, Competence Centre for Rare Esophageal Diseases University Hospital Center of Orl\u00e9ans Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Aumar","sequence":"additional","affiliation":[{"name":"Reference Centre for Rare Esophageal Diseases University of Lille, CHU Lille Lille 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