{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:28:18Z","timestamp":1780316898111,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Micronutrient deficiencies characterize classical \u201clate\u2010diagnosed\u201d celiac disease (CeD). This study aimed to identify the prevalence of micronutrient deficiencies among children with \u201cearly\u2010diagnosed\u201d screening\u2010identified CeD to determine the clinical value of routine testing for deficiencies in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was conducted on screening\u2010identified CeD patients diagnosed during a mass screening study (84 patients, mean age 11.3\u2009\u00b1\u20092.6 years). The controls (443 children, mean age 10.8\u2009\u00b1\u20092.5 years) were negative for celiac disease serological screening. Hemoglobin, serum levels of iron, ferritin, folate, vitamin B12, vitamin A, vitamin E, 25\u2010OH vitamin D, zinc, and selenium were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum levels of hemoglobin, iron, ferritin, vitamin D, zinc, copper, and selenium were significantly lower in CeD patients than in healthy controls (hemoglobin 12.56\u00a0vs. 13.02\u2009g\/dL\u00a0[<jats:italic>p<\/jats:italic>\u2009=\u20090.04]; iron 10.61\u00a0vs. 17.6\u2009\u00b5mol\/L [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], ferritin 25.7\u00a0vs. 48.3\u2009\u00b5g\/L [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], vitamin D 29.1 vs. 37.5\u2009nmol\/L, zinc 11.9 vs. 21.7\u2009\u00b5mol\/L, copper 18.9 vs. 32.5\u2009\u00b5mol\/L, selenium 1.04 vs. 1.36\u2009\u00b5mol\/L; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Patients with celiac and severe intestinal damage (Marsh IIIb and IIIc) had significantly lower serum ferritin and vitamin A levels than patients with mild intestinal damage (Marsh II and IIIa) (ferritin 15\u00a0vs. 22\u2009\u00b5g\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.025; vitamin A 0.85 vs.\u00a01.35\u2009\u00b5mol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Micronutrient deficiencies are still detectable in \u201cearly\u2010diagnosed\u201d screening\u2010identified CeD cases, a clinically relevant result that strongly supports efforts for screening and early diagnosis of CeD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12126","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T09:35:28Z","timestamp":1706002528000},"page":"677-684","source":"Crossref","is-referenced-by-count":6,"title":["Status of vitamins and minerals in children with screening\u2010identified celiac disease: A\u00a0case\u2010control study"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-9070","authenticated-orcid":false,"given":"Abdulrahman","family":"Al\u2010Hussaini","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Children's Specialized Hospital King Fahad Medical City Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University"},{"name":"Department of Pediatrics, Faculty of Medicine, Prince Abdullah bin Khalid Celiac Disease Research Chair King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Medical Translational Sciences &amp; European Laboratory for the Investigation of Food\u2010Induced Diseases University Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Alobaid","sequence":"additional","affiliation":[{"name":"Department of Nutrition King Fahad Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Salman","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Research Services Adminsitration, Research Center King Fahad Medical City Riyadh Riyadh Saudi 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