{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:06:46Z","timestamp":1781564806038,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent upper endoscopies are essential for monitoring therapy response and disease activity in patients with eosinophilic esophagitis (EoE), leading to increased costs, procedural complications, and anesthesia exposure. The aim of this study was to examine an office\u2010based model using serial sedation\u2010free blind esophageal epithelial brushing (BEEB) to monitor therapy response through eosinophil\u2010derived neurotoxin (EDN) levels and guide therapy plans in pediatric EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EoE patients (\u226421 years of age) were enrolled in this prospective study. Subjects were placed on dietary, pharmacologic, or combination therapy with the goal of inducing or maintaining remission. To assess response to sequential interventions, subjects underwent sequential sedation\u2010free BEEBs through nasogastric tubes\u00a0to measure EDN levels. Based on serial brushings, an individual plan of diet, medications, or a combination of both was created for each subject, and a final endoscopy was then performed to validate the accuracy of the individual plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four subjects completed the study. The average peak eosinophil count\u00a0in patients with active EoE was 58.1\u2009\u00b1\u200930.8 eosinophils per high\u2010power field and mean EDN level was 165.2\u2009\u00b1\u2009191.3\u2009\u03bcg\/mL. A total of 42 BEEBs were completed. Individual therapy plans based on sequential BEEB were accurate in 19 out of the 24 patients (79%) and specifically nine out of 10 patients (90%) treated with elimination diets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that office\u2010based sedation\u2010free BEEBs can be used to monitor therapy response and disease activity in pediatric EoE patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12127","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T09:39:35Z","timestamp":1706002775000},"page":"878-885","source":"Crossref","is-referenced-by-count":3,"title":["Monitoring pediatric eosinophilic esophagitis disease activity using an unsedated blind esophageal brushing model: A pilot study"],"prefix":"10.1002","volume":"78","author":[{"given":"Jessina","family":"Thomas","sequence":"first","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children at Orlando Health Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirajyoti","family":"Deb","sequence":"additional","affiliation":[{"name":"Pediatric Specialty Diagnostic Gastroenterology Translational Lab Arnold Palmer Hospital for Children at Orlando Health Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Bittar","sequence":"additional","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children at Orlando Health Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children at Orlando Health Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Mehta","sequence":"additional","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children at Orlando Health Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamen","family":"Smadi","sequence":"additional","affiliation":[{"name":"Eosinophilic Esophagitis Center, Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children at Orlando Health Orlando Florida 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