{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:08Z","timestamp":1788871988496,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether proton pump inhibitor (PPI)\u00a0exposure is associated with an increased risk of developing eosinophilic esophagitis (EoE) in children with esophageal atresia (EA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A retrospective chart review of children with EA from January 1, 2005 to December\u00a031, 2020 was undertaken at Sydney Children's Hospital Randwick. Children with EA and EoE (cases) were matched (1:2) to children with only EA (controls) to compare PPI exposure. Other early\u2010life factors such as infantile antibiotic exposure and personal or family history of atopy were also analyzed using simple and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 184 children with EA, 46 (25%) developed EoE during this period. Thirty\u2010eight EoE participants were matched to 76 controls. Children with EoE and EA received PPI for significantly higher durations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018) and at significantly higher cumulative doses (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017) than controls. Food allergy (adjusted odds ratio [aOR],\u00a07.317; 95% confidence interval [CI],\u00a02.244\u201323.742), family history of atopy (aOR,\u00a03.504; 95% CI, 1.268\u20139.682), and infantile antibiotic exposure (aOR,\u00a01.040; 95% CI, 1.006\u20131.075) were also significantly associated with an increased risk of developing EoE in the EA cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prolonged duration and high cumulative dose of PPI exposure were significantly associated with subsequent EoE development in children with EA. Food allergy, family history of atopy, and infantile antibiotic exposure in EA were also significantly associated with an increased risk of EoE development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.12129","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T01:40:19Z","timestamp":1708998019000},"page":"1317-1328","source":"Crossref","is-referenced-by-count":15,"title":["Proton pump inhibitors, antibiotics, and atopy increase the risk of eosinophilic esophagitis in children with esophageal atresia"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-3728","authenticated-orcid":false,"given":"Tiffany C.","family":"Tang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Discipline of Pediatrics, Faculty of Medicine and Health University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Leach","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Pediatrics, Faculty of Medicine and Health University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Krishnan","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Discipline of Pediatrics, Faculty of Medicine and Health University of New South Wales Sydney Australia"},{"name":"Department of Pediatric Gastroenterology Sydney Children's Hospital Randwick Sydney 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