{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:56:27Z","timestamp":1783443387271,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of functional constipation (FC) in children with autism spectrum disorder (ASD) is challenging due to sensory and behavioral issues. We aimed to understand whether antegrade continence enemas (ACEs) are successful in the treatment of FC in children with ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010institution retrospective review was performed in children diagnosed with ASD and FC who underwent appendicostomy or cecostomy placement from 2007 to 2019. Descriptive statistics regarding soiling and complications were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 33 patients included, with a median age of 9.7 years at the time of ACE initiation. The average intelligence quotient was 63.6 (<jats:italic>SD<\/jats:italic>\u2009=\u200918.0, <jats:italic>n<\/jats:italic>\u2009=\u200912), the average behavioral adaptive score was 59.9 (<jats:italic>SD<\/jats:italic>\u2009=\u200911.1, <jats:italic>n<\/jats:italic>\u2009=\u200913), and the average total Child Behavioral Checklist score was 72.5 (<jats:italic>SD<\/jats:italic>\u2009=\u20097.1, <jats:italic>n<\/jats:italic>\u2009=\u200910). Soiling rates were significantly lower following ACE initiation (42.3% vs. 14.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Behavioral issues only prevented 1 patient (3.0%) from proper ACE use. Eleven patients (36.6%) were able to transition to laxatives. There were significant improvements in patient\u2010reported outcomes measures and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placement of an appendicostomy or cecostomy for management of FC in children with severe ASD was successful in treating constipation and improving quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12130","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T13:35:15Z","timestamp":1706535315000},"page":"810-816","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of children with constipation and autism spectrum disorder treated with antegrade continence enemas"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-7843","authenticated-orcid":false,"given":"Shruthi","family":"Srinivas","sequence":"first","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Halaweish","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Knaus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine L.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Psychology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Yossef","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Trimble","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta L. Negri","family":"Jimenez","sequence":"additional","affiliation":[{"name":"College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gasior","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3995"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003662"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2933"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.939"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2775-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.004"},{"issue":"16","key":"e_1_2_7_8_1","first-page":"00181","article-title":"Functional disorders: children and adolescents","volume":"0016","author":"Hyams JS","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64116-X"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"402","article-title":"Management of intractable constipation with antegrade enemas in neurologically intact children","volume":"34","author":"Youssef NN","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.04.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.12.032"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.01.070"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02056950"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.03.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.5.6.705"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12691"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12810"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01867.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.01.042"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.04.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0900H"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-018-9587-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4128-x"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:17:31Z","timestamp":1718183851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jpn3.12130"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12130","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}