{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T04:15:25Z","timestamp":1726805725730},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A\u2013E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant\u00a0or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan\u2010lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.<\/jats:p>","DOI":"10.1002\/jpn3.12133","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T08:30:58Z","timestamp":1707381058000},"page":"534-538","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022"],"prefix":"10.1002","volume":"78","author":[{"given":"Helen","family":"Callaby","sequence":"first","affiliation":[{"name":"UKHSA Rare and Imported Pathogen Laboratory Porton Down London UK"},{"name":"Institute of Medical Sciences University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"McGuire","sequence":"additional","affiliation":[{"name":"HCAI, Fungal, AMR AMU &amp; Sepsis Division, UKHSA London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Rajwal","sequence":"additional","affiliation":[{"name":"Leeds Children's Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Stahlschmidt","sequence":"additional","affiliation":[{"name":"Department of Histopathology and Molecular Pathology, St James's University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Hartley","sequence":"additional","affiliation":[{"name":"Liver Unit Birmingham Women's and Children's Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Histopathology Birmingham Children's Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maesha","family":"Deheragoda","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Quaglia","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Royal Free London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Rampling","sequence":"additional","affiliation":[{"name":"UKHSA Rare and Imported Pathogen Laboratory Porton Down London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine F.","family":"Houlihan","sequence":"additional","affiliation":[{"name":"UKHSA Rare and Imported Pathogen Laboratory Porton Down London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Claire Gordon","sequence":"additional","affiliation":[{"name":"UKHSA Rare and Imported Pathogen Laboratory Porton Down London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin S.","family":"Brown","sequence":"additional","affiliation":[{"name":"HCAI, Fungal, AMR AMU &amp; Sepsis Division, UKHSA London UK"},{"name":"NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Simmons","sequence":"additional","affiliation":[{"name":"Blood Safety, Hepatitis, STI &amp; HIV Division UK Health Security Agency London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anda","family":"Samson","sequence":"additional","affiliation":[{"name":"HCAI, Fungal, AMR AMU &amp; Sepsis Division, UKHSA London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Mandal","sequence":"additional","affiliation":[{"name":"Blood Safety, Hepatitis, STI &amp; HIV Division UK Health Security Agency London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tassos","family":"Grammatikopoulos","sequence":"additional","affiliation":[{"name":"Paediatric Liver, GI &amp; Nutrition Centre and Mowat Labs King's College Hospital London UK"},{"name":"Institute of Liver Studies King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Demirjian","sequence":"additional","affiliation":[{"name":"HCAI, Fungal, AMR AMU &amp; Sepsis Division, UKHSA London UK"},{"name":"Department of Paediatric Infectious Diseases &amp; Immunology Evelina London Children's Hospital London UK"},{"name":"Faculty of Life Sciences &amp; Medicine King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Acute Hepatitis of Unknown Aetiology in Children\u2014Multicountry. WHO; 2022.https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON400"},{"key":"e_1_2_7_3_1","unstructured":"United Kingdom Health Security Agency.Investigation into Acute Hepatitis of Unknown Aetiology in Children in England Technical Briefing 4. United Kingdom Health Security Agency; 2022.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1094573\/acute-hepatitis-technical-briefing-4.pdf"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05948-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06003-w"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206704"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06765-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0527-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16992"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2018.02.009"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T07:29:03Z","timestamp":1726730943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,8]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jpn3.12133"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12133","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"type":"print","value":"0277-2116"},{"type":"electronic","value":"1536-4801"}],"subject":[],"published":{"date-parts":[[2024,2,8]]}}}