{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:40:12Z","timestamp":1779316812141,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatric FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a single\u2010blinded, randomized controlled study, we included 280 patients aged 8\u201318 years with FC. Patients were randomized either to a weight\u2010based lubiprostone dose (<jats:italic>n<\/jats:italic>\u2009=\u2009140) or conventional laxatives (<jats:italic>n<\/jats:italic>\u2009=\u2009140), including lactulose, bisacodyl, or sodium picosulfate, for 12 weeks, followed by 4 weeks posttreatment follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvement in constipation was achieved in 128 (91.4%) patients in the lubiprostone group, and in 48 (34.3%) patients of the conventional therapy group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and was sustained after treatment discontinuation. One quarter of the lubiprostone group experienced the first spontaneous bowel motion within 48\u2009h after dose initiation. A total of 75.7% of the lubiprostone group could achieve and sustain Bristol stool form of 3 or 4 during the last 4 weeks of therapy and through the 4 weeks of follow\u2010up versus 50 (35.7%) patients in the conventional therapy group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No life\u2010threatening adverse drug reactions were encountered, and no treatment\u2010related discontinuation. Mild self\u2010limited colicky abdominal pain and headache were the most prevalent side effects in the lubiprostone group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lubiprostone is an effective and well\u2010tolerated pharmacotherapy for youthful age and pediatric age groups, which may alter the paradigm of pediatric FC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12135","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:19:36Z","timestamp":1707290376000},"page":"800-809","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial"],"prefix":"10.1002","volume":"78","author":[{"given":"Engy S.","family":"Elkaragy","sequence":"first","affiliation":[{"name":"Department of Pediatrics Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M.","family":"Shamseya","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Internal Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha H.","family":"Metwally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman R.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine, Rheumatology, and Rehabilitation, Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-1338","authenticated-orcid":false,"given":"Sameh A.","family":"Lashen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Hepatology &amp; Gastroenterology Division), Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00771.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S110940"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.35"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v11.i5.385"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00528.2003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S2938"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00264.2005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000176"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.04.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003280"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/24.1.39"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01983.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000399"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.3.277"},{"key":"e_1_2_8_19_1","first-page":"6","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"12","author":"Ohkusa T","year":"2019","journal-title":"Front Med"},{"key":"e_1_2_8_20_1","article-title":"Phase III. 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