{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:50:37Z","timestamp":1754398237960,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pharyngeal contractile integral (PhCI) is the product of mean pharyngeal contractile amplitude, length, and duration, and provides a single metric for the vigor of entire pharyngeal contraction. A major limitation in children is lack of characterization of PhCI on high\u2010resolution pharyngeal manometry. We aimed to determine and compare the values of PhCI in children with the abnormal and normal videofluoroscopic study of swallow (VFSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children who underwent high\u2010resolution pharyngeal and esophageal manometry (HRPM\/HREM), as well as VFSS, were divided into two groups; \u201cnormal VFSS\u201d and \u201cabnormal VFSS\u201d groups. PhCI was calculated from the pharyngo\u2010esophageal manometry analysis software (MMS, v9.5, Laborie Medical Technologies), and compared in these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 67 children, 9 had abnormal VFSS (mean age 64\u2009\u00b1\u200950 months; 66.7% males), while 58 had normal VFSS (mean age 123\u2009\u00b1\u200955 months; 47% males). The mean PhCI in abnormal and normal VFSS groups was 82.00\u2009\u00b1\u200951.90 and 147.28\u2009\u00b1\u200953.89\u2009mmHg.s.cm, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Subjects with abnormal VFSS were significantly younger than those with normal VFSS (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). However, after adjusting for the VFSS result, age was no longer related to PhCI (<jats:italic>p<\/jats:italic>\u2009=\u20090.364). In subgroup analysis of children presenting with dysphagia, the mean PhCI in abnormal (9 subjects) and normal (36 subjects) VFSS groups was 82.00\u2009\u00b1\u200951.90 and 141.86\u2009\u00b1\u200950.39\u2009mmHg.s.cm, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PhCI was significantly lower in children with abnormal VFSS than in those with normal VFSS. We did not find a significant impact of age on PhCI in our pediatric populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12140","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:48:48Z","timestamp":1707292128000},"page":"783-789","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of pharyngeal contractile integral using pharyngeal manometry in children"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-5953","authenticated-orcid":false,"given":"Alisara","family":"Damrongmanee","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Chiang Mai University Chiang Mai Thailand"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Santucci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Fei","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Cincinnati Children's Hospital Medical Center Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.07.047"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.199"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.09.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000492"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2017.12.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10023-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13144"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0552-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13962"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14184"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13239"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99070-w"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0097-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-020-10217-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13119"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-022-10417-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12769"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17549507.2021.1975817"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-012-9423-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15095"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:19:04Z","timestamp":1718183944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jpn3.12140"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12140","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"type":"print","value":"0277-2116"},{"type":"electronic","value":"1536-4801"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}