{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T21:08:12Z","timestamp":1761253692877},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The incidence of eosinophilic esophagitis (EoE) is 3\u22125 times greater in patients with inflammatory bowel disease (IBD) compared with the general population. This study aimed to differentiate true EoE from esophageal eosinophilia in IBD\u00a0patients by evaluating expression of major basic protein (MBP) and interleukin\u201013 (IL\u201013) in esophageal biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included subjects who had an esophagogastroduodenoscopy with esophageal biopsies for IBD work up or suspicion for EoE. Patients were classified into 5 groups: EoE with \u226515 eosinophils per high power field (eos\/hpf), EoE\u2010IBD with \u226515 eos\/hpf, IBD eosinophilia with 1\u221214 eos\/hpf, IBD and control groups. Biopsies were stained with MBP and IL\u201013 antibodies and the results (% staining\/total tissue area), demographic, and clinical findings were compared among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median for MBP staining levels in EoE\u2010IBD was 3.8 (interquartile range 1.3\u221223), significantly lower than in EoE at 52.8 (8.3\u2212113.2), but higher than in IBD eosinophilia at 0.2 (0\u22120.9; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and negligible in the IBD and control groups. IL\u201013 expression in EoE was significantly higher only compared with IBD and controls not with EoE\u2010IBD or IBD eosinophilia. MBP predicted EoE with 100% sensitivity and 99% specificity while IL\u201013 had 83% sensitivity and 90% specificity using cutoff point from the cohort without EoE\u2010IBD patients. Based on MBP cutoff point that distinguished EoE from non EoE, 56% in EoE\u2010IBD were MBP\u2010positive whereas 100% in EoE group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MBP may be an excellent marker in distinguishing true EoE from eosinophilia caused by IBD. Our data implied that MBP together with endoscopic and histologic changes can assist EoE diagnosis in IBD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12143","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:29:10Z","timestamp":1707290950000},"page":"555-564","source":"Crossref","is-referenced-by-count":2,"title":["Major basic protein is a useful marker to distinguish eosinophilic esophagitis from IBD\u2010associated eosinophilia in children"],"prefix":"10.1002","volume":"78","author":[{"given":"Samantha","family":"Butzke","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology Nemours Children's Health Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaida","family":"Nasiri\u2010Blomgren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Nemours Children's Health Wilmington Delaware 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