{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:32:44Z","timestamp":1776317564562,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Remote investigation and monitoring have gained importance in ambulatory practice. A home\u2010based fecal calprotectin (FC) test has been developed where the sample is processed and analyzed at home through a smartphone application. We aimed to assess the use of standard ELISA (sFC) versus home\u2010based (hFC) FC\u00a0testing in a general pediatric gastroenterology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ambulatory pediatric patients with hFC\u00a0or sFC performed between August 2019 and November 2020 were included. Data regarding demographics, clinical characteristics, medication use, investigations, and final diagnosis, categorized as inflammatory bowel disease (IBD), functional gastrointestinal (GI) disorders, organic non\u2010IBD (ONI) GI disorders, non\u2010GI disorders, and undetermined after 6 months of investigation, were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 453 FC tests from 453 unique patients were included. Of those, 249 (55%) were hFC. FC levels (median) were higher in children with IBD compared to non\u2010IBD diagnosis (sFC 795 vs. 57\u2009\u03bcg\/g, hFC 595 vs. 47\u2009\u03bcg\/g, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and in ONI compared to functional GI disorders (sFC 85 vs. 54\u2009\u03bcg\/g, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, hFC 57 vs. 40\u2009\u03bcg\/g, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant difference was observed between different ONI GI disorders or subtypes of functional disorders. Age did not significantly influence levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, hFC and sFC provide similar results in the general pediatric GI ambulatory setting. FC is a sensitive but not disease\u2010specific marker to identify patients with IBD. Values appear to be higher in ONI GI disorders over functional disorders, although cut\u2010off values have yet to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12150","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:56:40Z","timestamp":1707296200000},"page":"790-799","source":"Crossref","is-referenced-by-count":3,"title":["Home\u2010based fecal calprotectin utilization in a general pediatric gastroenterology clinic"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-8297","authenticated-orcid":false,"given":"Melanie L.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University London Ontario Canada"},{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology &amp; Hepatology, Children's Hospital of Western Ontario London Health Sciences Center London Ontario Canada"},{"name":"Children's Health Research Institute London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"McCrady","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Lee","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence","family":"Bowerbank","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University London Ontario Canada"},{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology &amp; 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