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Direct\u2010acting antiviral regimens are safe and effective. Three regimens with pangenotypic activity (glecaprevir\/pibrentasvir, sofosbuvir\/velpatasvir and sofosbuvir\/velpatasvir\/voxilaprevir) and three regimens with genotype\u2010specific activity (sofosbuvir\/ribavirin, sofosbuvir\/ledipasvir and elbasvir\/grazoprevir) have been approved with age\u2010specific limitation for treatment of children with chronic hepatitis C by the European Medicines Agency and the United States Food and Drug Administration. The World Health Organization has set the ambitious target to eliminate hepatitis C as a major public health threat by 2030 and based its actions against HCV on the large use of direct acting antivirals. These updated European Society for Pediatric Gastroenterology, Hepatology and Nutrition recommendations on treatment of hepatitis C describe the optimal therapeutic management of adolescents and children with HCV infection including specific indications for those living in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/jpn3.12160","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:57:00Z","timestamp":1708329420000},"page":"957-972","source":"Crossref","is-referenced-by-count":22,"title":["ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource\u2010limited settings"],"prefix":"10.1002","volume":"78","author":[{"given":"Giuseppe","family":"Indolfi","sequence":"first","affiliation":[{"name":"Department NEUROFARBA University of Florence Florence Italy"},{"name":"Paediatric and Liver Unit Meyer Children's Hospital IRCCS Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regino P.","family":"Gonzalez\u2010Peralta","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Liver Transplant, AdventHealth for Children AdventHealth Transplant Institute Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen M.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Hamdy\u2010El","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Children's Hospital Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Fischler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Karolinska University Hospital, CLINTEC Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Sokal","sequence":"additional","affiliation":[{"name":"UCLouvain, Cliniques Universitaires St Luc Pediatric Hepatology Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Helios University Hospital Wuppertal Witten\u2010Herdecke University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Nicastro","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Transplantation Hospital Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Hepatology Committee of the ESPGHAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001872"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30385-1"},{"issue":"17","key":"e_1_2_20_4_1","first-page":"537","article-title":"Hepatitis C virus infection among adolescents and young adults:massachusetts, 2002\u20132009","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30046-9"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.082"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003481"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1070668"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/785627"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.013"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30037-3"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16037"},{"key":"e_1_2_20_13_1","doi-asserted-by":"crossref","unstructured":"IndolfiG EasterbrookP GiomettoS et al. 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