{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:34:06Z","timestamp":1790969646054,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Percutaneous electrical nerve field stimulation (PENFS) has demonstrated promise in single\u2010center trials for pediatric abdominal pain\u2010related disorders of gut\u2013brain interaction (DGBI). Our aim was to explore efficacy of PENFS as standard therapy for DGBI in a registry involving multiple pediatric gastroenterology referral centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, prospective open\u2010label registry of children (8\u201318 years) undergoing PENFS for DGBI at seven tertiary care gastroenterology clinics. DGBI subtypes were classified by Rome IV criteria. Parents and patients completed Abdominal Pain Index (API), Nausea Severity Scale (NSS), and Functional Disability Inventory (FDI) questionnaires before, during therapy and at follow\u2010up visits up to 1 year later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 292 subjects were included. Majority (74%) were female with median (interquartile range [IQR]) age 16.3 (14.0, 17.7) years. Most (68%) met criteria for functional dyspepsia and 61% had failed \u22654 pharmacologic therapies. API, NSS, and FDI scores showed significant declines within 3 weeks of therapy, persisting long\u2010term in a subset. Baseline (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009288) median (IQR) child\u2010reported API scores decreased from 2.68 (1.84, 3.58) to 1.99 (1.13, 3.27) at 3 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 1.81 (0.85, 3.20) at 3 months (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). NSS scores similarly improved from baseline, persisting at three (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200974;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 6 months later (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). FDI scores displayed similar reductions at 3 months (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) but not beyond. Parent\u2010reported scores were consistent with child reports.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large, comprehensive, multicenter registry highlights efficacy of PENFS for gastrointestinal symptoms and functionality for pediatric DGBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.12174","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T08:33:53Z","timestamp":1709800433000},"page":"817-826","source":"Crossref","is-referenced-by-count":20,"title":["A multicenter registry study on percutaneous electrical nerve field stimulation for pediatric disorders of gut\u2013brain interaction"],"prefix":"10.1002","volume":"78","author":[{"given":"Ashish","family":"Chogle","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition Children's Hospital of Orange County Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Hepatology and Nutrition &amp; Division of Quantitative Health Sciences Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahleb","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition Atrium Health Levine Children's Hospital Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Dranove","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition Atrium Health Levine Children's Hospital Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rosen","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology Children's Hospital Boston Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology Children's Hospital Boston Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Croffie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Riley Hospital for Children Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshawadhana","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Hepatology and Nutrition &amp; Division of Quantitative Health Sciences Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Pediatric Gastroenterology, Hepatology and Nutrition &amp; 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