{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:27:15Z","timestamp":1773030435019,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients with intestinal failure require central venous access which puts them at risk for central line\u2010associated bloodstream infections (CLABSI). Maintaining vascular patency is critical for this population to receive nutrition support. When CLABSIs occur line salvage can help maintain vascular access. The aim of this study is to assess factors associated with safe and successful central venous catheter salvage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of patients with intestinal failure at two tertiary care institutions between 2012 and 2020. The study examined the rates of attempted salvage, factors associated with successful salvage, and complications associated with salvage attempts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the study period, 76 patients with intestinal failure were include while central venous access was in place. There were a total of 94 CLABSIs. Salvage was more likely to be attempted when patients were under the direct care of an intestinal rehabilitation service (95% vs. 68%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). The overall successful salvage rate was 91.6% (<jats:italic>n<\/jats:italic>\u2009=\u200977). Gram\u2010positive, Gram\u2010negative, and polymicrobial infections had successful salvage rates of 97%, 92%, and 94% respectively. The successful salvage rate for fungal infections was 40%. There was no difference in 30\u2010day complication rates for hospital readmission, intensive care unit admission, and death between patients who underwent salvage attempt and those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Central line salvage can be safely attempted for many infections in patients with intestinal failure, leading to vascular access preservation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12175","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T13:33:56Z","timestamp":1709818436000},"page":"918-926","source":"Crossref","is-referenced-by-count":6,"title":["Catheter salvage from central line\u2010related bloodstream infections in pediatric intestinal failure"],"prefix":"10.1002","volume":"78","author":[{"given":"Catherine","family":"Larson\u2010Nath","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Hepatology, and Nutrition University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linder","family":"Wendt","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riad","family":"Rahhal","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hepatology, and Nutrition University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113517716"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420010027004"},{"key":"e_1_2_6_3_2","unstructured":"discussion24\u20102."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000812"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001722"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.031"},{"key":"e_1_2_6_7_1","unstructured":"National Healthcare Safety Network.Bloodstream Infection event (central line\u2010associated bloodstream infection and noncentral line\u2010associated bloodstream infection. Centers for Disease Control and Prevention. Accessed November 11 2023.\u00a0https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/4psc_clabscurrent.pdf"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003036"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117722753"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-042069"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00427"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4165-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2022.03.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0702.010226"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28856"},{"issue":"7","key":"e_1_2_6_17_1","article-title":"Central venous catheter (CVC) removal for patients of all ages with candidaemia","volume":"7","author":"Janum S","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182784867"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:17:09Z","timestamp":1718183829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jpn3.12175"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12175","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}