{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:25:16Z","timestamp":1776961516137,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Autoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen\u00a0(HLA)\u2010genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included were 13,860 HLA\u2010DQ\u2010genotyped children at birth and previously invited to a screening at age 3 and 9 years, respectively. HLA\u2010DQB1*02 and\/or DQB1*03:02 (HLA\u2010risk) children were compared with non\u2010HLA\u2010DQB1*02 and non\u2010DQB1*03:02 (HLA\u2010nonrisk) children. The present study reinvited 12,948\/13,860 (93.4%) children at age 15 years of whom 1056\/2374 (44.5%) participated in screening at both age 3 and 9 years. Both immunoglobulin A (IgA) and G (IgG) autoantibodies against tTG were analyzed separately in radiobinding assays. Persistently tTG autoantibody\u2010positive children were examined with intestinal biopsy to confirm the diagnosis of celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At age 3 years, celiac disease was diagnosed in 56\/1635 (3.4%) HLA\u2010risk children compared with 0\/1824 HLA\u2010nonrisk children (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). By age 9 years, celiac disease was diagnosed in 72\/1910 (3.8%) HLA\u2010risk children compared with 0\/2167 HLA\u2010nonrisk children (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Screening at age 15 years detected 14\/1071 (1.3%) HLA\u2010risk children positive for IgA\u2010tTG and\/or IgG\u2010tTG of whom 12\/1071 (1.1%) remained persistently positive. Among those, 10\/1071 (0.9%, 95% confidence interval: 0.4%\u20131.7%) HLA\u2010risk children were diagnosed with celiac disease compared with 0\/1303 HLA\u2010nonrisk children (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 5\/491 (1.0%) were negative in screenings at both 3 and 9 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Screening for celiac disease needs to be performed at multiple timepoints to detect all cases but can be restricted to children at HLA\u2010risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12181","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:53:44Z","timestamp":1710327224000},"page":"1143-1148","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal screening of HLA\u2010risk and HLA\u2010nonrisk children for celiac disease to age 15 years: CiPiS study"],"prefix":"10.1002","volume":"78","author":[{"given":"Michaela","family":"Bostr\u00f6m","sequence":"first","affiliation":[{"name":"Celiac Disease and Diabetes Unit Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Brundin","sequence":"additional","affiliation":[{"name":"Celiac Disease and Diabetes Unit Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Bj\u00f6rck","sequence":"additional","affiliation":[{"name":"Celiac Disease and Diabetes Unit Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Agardh","sequence":"additional","affiliation":[{"name":"Celiac Disease and Diabetes Unit Lund University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3765"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614561668"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001568"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051695"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010142"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369541"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.505931"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10395"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b477a6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000946"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.619564"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00408469"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03036.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10329"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.04.030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000751"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"issue":"9","key":"e_1_2_10_23_1","first-page":"17","article-title":"Genetic 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