{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:59:46Z","timestamp":1789685986708,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We evaluated patients aged 12\u201320 on dupilumab 300\u2009mg weekly for treatment of eosinophilic esophagitis (EoE) who had \u22651 follow\u2010up endoscopy at a tertiary care pediatric hospital (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918). Fifty percent had inflammatory EoE (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), 22% had fibrostenotic EoE (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094), and 28% had non\u2010EoE eosinophilic gastrointestinal disease (EGID) with esophageal involvement (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095). Ninety\u2010four percent discontinued topical corticosteroids (TCS) 2\u20134 weeks after starting dupilumab. Eighty\u2010nine percent of inflammatory EoE patients had histological\n                    <jats:italic>response<\/jats:italic>\n                    (&lt;15\u2009eosinophils\/high\u2010powered field) after an average of 19.1 weeks. One hundred percent of patients with fibrostenotic disease exhibited histological\n                    <jats:italic>response<\/jats:italic>\n                    after 16.8 weeks. Of patients with non\u2010EoE EGID, 60% achieved esophageal histological\n                    <jats:italic>response<\/jats:italic>\n                    after an average of 40.1 weeks. In a small cohort, dupilumab was very effective for adolescent inflammatory and fibrostenotic EoE despite rapid weaning of TCS. Dupilumab was also somewhat effective for non\u2010EoE EGID with esophageal involvement; however, a longer duration of therapy was required.\n                  <\/jats:p>","DOI":"10.1002\/jpn3.12187","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T06:29:50Z","timestamp":1712557790000},"page":"1337-1341","source":"Crossref","is-referenced-by-count":7,"title":["Dupilumab in adolescent eosinophilic esophagitis: Experience with fibrostenosis and eosinophilic gastrointestinal disease with esophageal involvement"],"prefix":"10.1002","volume":"78","author":[{"given":"Robert","family":"Becker","sequence":"first","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition,\u00a0Division of Pediatric Gastroenterology Medical College of Wisconsin\/Children's Hospital of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Rigsby","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Children's Hospital of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Suchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin\/Children's Hospital of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana G.","family":"Lerner","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition,\u00a0Division of Pediatric Gastroenterology Medical College of Wisconsin\/Children's Hospital of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-3440","authenticated-orcid":false,"given":"Ankur","family":"Chugh","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition,\u00a0Division of Pediatric Gastroenterology Medical College of Wisconsin\/Children's Hospital of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205982"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000887"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003512"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"1","article-title":"Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring","volume":"30","author":"Collins MH","year":"2017","journal-title":"Dis Esophagus"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003877"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.07.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.08.015"},{"key":"e_1_2_8_10_1","unstructured":"Dupilumab in eosinophilic gastritis. ClinicalTrials.Gov. Accessed September 28 2023.https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03678545"},{"issue":"9","key":"e_1_2_8_11_1","first-page":"3494","article-title":"Unsedated transnasal esophagoscopy with virtual reality distraction enables earlier monitoring of dietary therapy in eosinophilic esophagitis","volume":"9","author":"Friedlander JA","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00204-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.03.047"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003552"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.01.019"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:35:32Z","timestamp":1728866132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jpn3.12187"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12187","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]}}}