{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:26:56Z","timestamp":1788910016500,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective of this study is to further explore associations between social influencers of health and markers of disease severity at the time of presentation of patients with pediatric metabolic dysfunction\u2010associated steatotic liver disease (MASLD) using neighborhood\u2010level Area Deprivation Index (ADI) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional study was conducted among 344 pediatric MASLD patients. Each patient received an ADI score based on their 9\u2010digit zip code. Groups were defined as low (\u22645) and high (6\u2265) ADI. Associations between ADI and symptomatology and laboratory values at presentation, as well as initial liver biopsy pathology were tested via analyses of covariance, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> testing, and logistic regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean ADI was 6.54 (standard deviation\u2009=\u20092.09). ADI groups did not significantly differ in age of presentation, type of presentation, or associated conditions, except for the higher ADI group having on average lower vitamin D levels (26.70 vs. 29.91, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and being two times more likely to also be diagnosed with low high\u2010density lipoprotein (HDL) levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.04, 95% CI\u00a01.04\u20133.89). Mean transaminases and histopathologic nonalcoholic fatty liver disease (NAFLD) Activity Scores did not significantly differ between ADI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric patients with MASLD in this study span the entire spectrum of neighborhood deprivation. There were no differences in presentation characteristics or severity of MASLD, aside from lower HDL\u2010cholesterol and vitamin D values in the high ADI group. Area deprivation was not predictive of more severe disease as assessed by serum transaminases and liver biopsy NAFLD activity scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12218","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T10:18:06Z","timestamp":1713262686000},"page":"1355-1363","source":"Crossref","is-referenced-by-count":3,"title":["Correlating neighborhood\u2010level deprivation and pediatric metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"78","author":[{"given":"Nicole E.","family":"Hickman","sequence":"first","affiliation":[{"name":"San Diego School of Medicine University of California La Jolla California USA"},{"name":"Department of Pediatrics Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason","family":"Price","sequence":"additional","affiliation":[{"name":"San Diego School of Medicine University of California La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noe C.","family":"Crespo","sequence":"additional","affiliation":[{"name":"School of Public Health, Division of Health Promotion and Behavioral Science San Diego State University San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel E.","family":"Feldstein","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition, Rady Children's Hospital University of California San Diego (UCSD) La Jolla California USA"},{"name":"Global Drug Discovery Novo Norodisk Bagsv\u00e6rd Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001482"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140908"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.171280"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.01.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0674-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2440-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002527"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-060640"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2107C"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.suppl_1.S37"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-019-00357-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1802313"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.93.7.1137"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000598"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2013.56.10.417"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04243-4"},{"key":"e_1_2_7_20_1","first-page":"1109","volume-title":"Metabolism","author":"Katsiki N","year":"2016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3280208519"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000455"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1746-0"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:34:59Z","timestamp":1728880499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,16]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jpn3.12218"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12218","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,16]]}}}