{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:11Z","timestamp":1789753271315,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Abnormal motility of the residual colon has been reported in post\u2010pull\u2010through Hirschsprung disease (PT\u2010HSCR) patients with persistent defecation problems. We reviewed the role of colonic manometry (CM) in the management of defecation disorders in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We retrospectively reviewed the medical record of PT\u2010HSCR children who underwent CM for persistent symptoms of abnormal defecation. We reviewed their clinical course and its relation to CM findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Thirty PT\u2010HSCR patients underwent CM, of which five were diagnosed with transition zone pull\u2010through and were excluded. Of the remaining 25 patients, 16 had colonic dysmotility, 8 had normal CM, and one had colonic hypermotility. In patients with dysmotility, five responded to ongoing medical management, three required surgical intervention (ileostomy), three remained symptomatic with medical management but not yet received surgical intervention, and five were lost to follow\u2010up. In patients with normal CM, four responded to ongoing medical therapy, two required additional surgery (antegrade enema procedure), and two were lost to follow\u2010up. The patient with hypermotility improved with adding loperamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Colonic dysmotility can occur in PT\u2010HSCR patients with persistent defecation problems. CM was helpful in delineating the degree of colonic neuromuscular dysfunction. CM results were used in conjunction with other clinical data to determine optimal management. Our findings support that medical management should first be optimized before consideration of colonic manometry and surgical interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12227","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:00:42Z","timestamp":1714381242000},"page":"1217-1224","source":"Crossref","is-referenced-by-count":3,"title":["Utility of colonic manometry in children with Hirschsprung disease"],"prefix":"10.1002","volume":"78","author":[{"given":"Yinan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Children's Hospital Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gayer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital Los Angeles Los Angeles California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusine","family":"Ambartsumyan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Seattle Children's Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Punati","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Children's Hospital Los Angeles Los Angeles California 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