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Various infant formulas are marketed for their management and are frequently given by parents to infants before a medical consultation. However, the evidence supporting their effectiveness is limited and some have altered nutritional compositions when compared to standard formulas. Thus, these products should only be used under medical supervision and upon medical advice. Marketing and over\u2010the\u2010counter sales do not ensure proper medical guidance and supervision. The aim of this position paper is to review the current evidence regarding the safety and efficacy of formulas specifically formulated for addressing regurgitation, colic, and constipation, recognized as FGID. The objective is to provide guidance for clinical management based on the highest quality of available evidence. A wide search using Pubmed, MEDLINE, EMBASE and Cochrane Database of Systematic Reviews was performed including the MESH terms infant formula, colic, constipation, regurgitation, reflux, palmitate, lactase, lactose, magnesium, hydrolyzed protein, prebiotics or probiotics. 752 papers were identified and screened. Finally, 72 papers were included in the paper. In the absence of evidence, recommendations reflect the authors' combined expert opinion. Final consensus was obtained by multiple e\u2010mail exchange and meetings of the Nutrition Committee. (1) For breastfed infants experiencing FGID such as regurgitation, colic, or constipation, transitioning from breastfeeding to commercial formulas is not recommended. (2) In general, whether an infant is breastfed or formula\u2010fed, it's crucial to reassure parents that FGIDs are normal and typically do not necessitate treatment or change to a special formula. (3) Thickened formulas, often termed anti\u2010reflux formulas, may be considered in specific cases of regurgitation. (4) The usage of specialized formulas for infants with colic is not advised due to a lack of clinical evidence. (5) In the case of constipation in infants, the use of formulas enriched with high \u03b2\u2010palmitate and increased magnesium content may be considered to soften the stool. Generally, there is limited evidence supporting the use of specialized formulas for FGID. Breastfeeding should never be discontinued in favor of formula feeding.<\/jats:p>","DOI":"10.1002\/jpn3.12240","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T07:53:36Z","timestamp":1716191616000},"page":"168-180","source":"Crossref","is-referenced-by-count":17,"title":["Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee"],"prefix":"10.1002","volume":"79","author":[{"given":"Nadja","family":"Haiden","sequence":"first","affiliation":[{"name":"Department of Neonatology Kepler University Hospital Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Savino","sequence":"additional","affiliation":[{"name":"Department of Patologia e cura del bambino \u201cRegina Margherita\u201d Regina Margherita Children Hospital Azienda Ospedaliera Universitaria Citt\u00e0 della Salute e della Scienza di Torino Torino 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