{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:11:09Z","timestamp":1785849069199,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gastrointestinal (GI) manifestations in children with hypermobile Ehlers\u2013Danlos syndrome\/joint hypermobility syndrome (hEDS\/JHS) are not well described. We investigated the prevalence of GI disorders in children and young adults with hEDS\/JHS through a single\u2010center retrospective review. Demographic data, clinical history, symptoms, and diagnostic studies were reviewed. Of 435 patients with hEDS\/JHS, 66% were females (age 5\u221228 years). We noted a high prevalence of constipation (61%), dysphagia (32%), dyspepsia and\/or gastroparesis (25%), eosinophilic esophagitis (EoE) (21%), and celiac disease (4%) in our cohort. Upper endoscopy and gastric emptying scans had the highest yield to detect abnormalities. Motility studies were abnormal in 31% of the 80 patients who underwent them. Dysphagia symptoms are significantly associated with EoE. Thirty\u2010three percent of dysphagia patients had EoE, versus 16%\u00a0of non\u2010dysphagia patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Screening hEDS\/JHS patients for GI issues should be routine, with further investigations and referrals guided by identified symptoms.<\/jats:p>","DOI":"10.1002\/jpn3.12245","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T08:06:30Z","timestamp":1715760390000},"page":"42-47","source":"Crossref","is-referenced-by-count":15,"title":["High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility"],"prefix":"10.1002","volume":"79","author":[{"given":"Vibha","family":"Sood","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil I.","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Mukkada","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[{"name":"Biostatistics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fei","sequence":"additional","affiliation":[{"name":"Biostatistics Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-079X","authenticated-orcid":false,"given":"Neha R.","family":"Santucci","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31432"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"issue":"7","key":"e_1_2_8_4_1","first-page":"1777","article-title":"The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R","year":"2000","journal-title":"J 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