{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:24:00Z","timestamp":1768991040123,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In many cultures, \u201cfood as medicine\u201d has existed for centuries as the foundation of health. It is a practice built on the knowledge that food and diet play important roles in disease prevention and management. Foods possessing therapeutic properties are often referred to as functional foods. Many herbs and spices contain numerous nutritional and non\u2010nutritional components that can interact with pharmacologically relevant receptors, either directly or indirectly via their metabolites, to regulate cellular biochemical processes. Although opinions are changing, the concept of food as a therapeutic intervention goes against conventional Western medicine. To provide guidance to clinicians interested in using these products, members of the Food as Medicine working group of the Nutrition Committee NASPGHAN, as part of a two\u2010part review series, have identified frequently used foods, supplements, herbs, and spices that are utilized for therapeutic intent and have created summaries of commonly used indications, doses, and caveats. In this review, the focus is the use of select herbs and spices for medicinal purposes. Gaps in our knowledge in how to effectively use these agents in pediatric patients are discussed. Evidence supporting their use for management of gastrointestinal conditions, especially in the pediatric population, is provided when available. Circumstances in clinical settings and patient indications may require actions different from those recommended in this review and professional judgment should prevail.<\/jats:p>","DOI":"10.1002\/jpn3.12310","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T10:16:13Z","timestamp":1720520173000},"page":"473-484","source":"Crossref","is-referenced-by-count":3,"title":["From the kitchen to the medicine cabinet: Examples of functional herbs and spices"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-896X","authenticated-orcid":false,"given":"Kathleen","family":"Gura","sequence":"first","affiliation":[{"name":"Department of Pharmacy\/Division of Gastroenterology Hepatology, and Nutrition Boston Children's Hospital Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Duro","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition at Salah Foundation Children Hospital at Broward Health Fort Lauderdale Florida USA"},{"name":"Clinical Pediatrics at NOVA Southeastern University, Fort Lauderdale FL and Florida International University (FIU) Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences McMaster University Hamilton Ontario Canada"},{"name":"Division of Pediatric Gastroenterology &amp; Nutrition, McMaster Children's Hospital Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sandell","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology, and Nutrition at University of Rochester Medical Center Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthilkumar","family":"Sankararaman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology &amp; Nutrition. UH Rainbow Babies &amp; Children's Hospital Cleveland Ohio USA"},{"name":"Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Quiros\u2010Tejeira","sequence":"additional","affiliation":[{"name":"Pediatric Gatroentoerology, Hepatology &amp; Nutrition University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Herdes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition Stanford University School of Medicine Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Deas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Wang","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"issue":"1","key":"e_1_2_4_2_1","first-page":"44","article-title":"CPE monthly: health benefits of Chia\u2014learn about its history, nutrient composition, and current research regarding its health benefits","volume":"19","author":"Santora Zimmerman J","year":"2017","journal-title":"Today's Dietit"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.5430\/crim.v4n2p49"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-275"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.748503"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010088"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.04.002"},{"issue":"8","key":"e_1_2_4_8_1","first-page":"380","article-title":"Caffeine and psychiatric medication interactions: a review","volume":"98","author":"Broderick PJ","year":"2005","journal-title":"J Okla State Med Assoc"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01021"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2020.101252"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233712456065"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102154"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026621666211105094939"},{"key":"e_1_2_4_14_1","first-page":"347","article-title":"Cytochrome P450 enzyme mediated herbal drug interactions (part 1)","volume":"13","author":"Wanwimolruk S","year":"2014","journal-title":"EXCLI J"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010157"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809119444"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0264"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7769"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2008.11.005"},{"issue":"7","key":"e_1_2_4_20_1","first-page":"567","article-title":"Anaphylaxis associated with the ingestion of goji berries (Lycium barbarum)","volume":"21","author":"Monz\u00f3n Ballar\u00edn S","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Z442"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084121"},{"key":"e_1_2_4_23_1","volume-title":"Drugs and Lactation Database (LactMed\u00ae)","author":"Licorice","year":"2021"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200224666230116113240"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249653"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2014.019"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612829666230328163449"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109606"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3638"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.0055"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2023.7904"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.6.1552"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900281"},{"key":"e_1_2_4_34_1","volume-title":"WHO Monographs on Selected Medicinal Plants","author":"Cortex cinnamomi","year":"1999"},{"key":"e_1_2_4_35_1","unstructured":"Coffee | The Nutrition Source | Harvard T.H.Chan School of Public Health. 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