{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:13:47Z","timestamp":1782846827394,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significance of autoantibodies in pediatric metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is unknown. Our aim was to determine the prevalence and significance of autoantibodies in MASLD. PubMed and Scopus were searched and six articles (689 [487 males] MASLD patients) were identified. Antinuclear antibodies (ANA) was positive in 28% (95% confidence interval\u00a0[CI]: 17%\u201339%, <jats:italic>n<\/jats:italic>\u2009=\u20096 studies), antismooth muscle antibodies (ASMA) in 28% (95% CI: 8%\u201350%, <jats:italic>n<\/jats:italic>\u2009=\u20095 studies), actin\u2010positive in 15% (95% CI: 10%\u201320%, <jats:italic>n<\/jats:italic>\u2009=\u20092 studies) and elevated immunoglobulin G in 17% (95% CI: 1%\u201339%, <jats:italic>n<\/jats:italic>\u2009=\u20094 studies). Anti\u2010liver\u2010kidney\u2010microsomal antibody was not present in any patient. There was no significant association of ANA positivity with degree of liver steatosis, liver fibrosis or nonalcoholic fatty liver disease\u00a0activity score (NAS) but patients with ASMA positivity had advanced fibrosis (pooled risk ratio\u00a0[RR] 1.77; 95%\u00a0CI 1.16\u20132.71) and higher risk of NAS \u22655 (pooled RR 1.21; 95%\u00a0CI: 1.01\u20131.44, <jats:italic>n<\/jats:italic>\u2009=\u20092 studies, 243 patients). To conclude, non\u2010organ specific autoantibodies are present in over one\u2010fourth of children with MASLD and the presence of ASMA maybe associated with increased disease severity.<\/jats:p>","DOI":"10.1002\/jpn3.12311","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T08:49:00Z","timestamp":1720169340000},"page":"667-673","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and significance of autoantibodies in children with metabolic dysfunction\u2010associated steatotic liver disease: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-9761","authenticated-orcid":false,"given":"Rishi","family":"Bolia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Liver Transplant Queensland Children's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Semwal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Division of Paediatric Gastroenterology, All India Institute of Medical Sciences Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17096"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003534"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.08.041"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12696"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqac028"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13176"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3795-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-011-9277-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-009829"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/8446170","article-title":"Prevalence and significance of antinuclear antibodies in biopsy\u2010proven nonalcoholic fatty liver disease: a systematic review and meta\u2010analysis","volume":"2022","author":"Luo L","year":"2022","journal-title":"Dis Markers"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.10.004"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:34Z","timestamp":1727280994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jpn3.12311"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12311","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}