{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:57:49Z","timestamp":1791838669754,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Autoimmune gastritis (AIG) is a rare chronic inflammatory disorder with potential long\u2010term sequelae including gastric neoplasia. There is limited data on the natural history of pediatric AIG. We aimed to characterize the clinical course and outcomes of children with AIG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter retrospective study that included pediatric patients diagnosed with AIG between January 1, 2000 and December 31, 2021. Diagnosis of AIG was based on the demonstration of histological corpus\u2010predominant atrophic gastritis, with or without positive antiparietal cell (APCA) or anti\u2010intrinsic factor (IF) antibodies. Demographic, clinical, laboratory, endoscopic, and histologic data were retrieved, along with follow\u2010up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients, (23 females [69.7%], median age 12.0 [interquartile range 7.0\u201315.0] years at diagnosis) were identified. Twenty\u2010two patients (66.7%) had positive APCA and\/or anti\u2010IF serology. The most common presenting manifestation was iron deficiency anemia (75%), and accompanying autoimmune disorders were significantly more common in patients with positive serology (62% vs. 18%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Pseudo\u2010pyloric or intestinal\u2010type metaplasia was present at diagnosis in eight\u00a0patients (24%), and 11 additional patients (33%) developed metaplasia during a median follow\u2010up time of 27 (17.5\u201348.3) months. One patient developed a type 1 gastric neuroendocrine tumor.\u00a0<jats:italic>Helicobacter pylori<\/jats:italic>\u00a0was identified in only one patient, while two patients had prior eradication. Endoscopic and histologic improvements weren't identified in any patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AIG should be considered in patients with autoimmunity and resistant iron\u2010deficiency anemia. <jats:italic>H. pylori<\/jats:italic> infection may not be associated with pediatric AIG. The development of neuroendocrine tumor in one patient, and the high rates of metaplasia, highlight the importance of surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12318","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:19:43Z","timestamp":1721114383000},"page":"501-509","source":"Crossref","is-referenced-by-count":9,"title":["Clinical characteristics and outcomes of pediatric patients with autoimmune gastritis"],"prefix":"10.1002","volume":"79","author":[{"given":"Maya","family":"Granot","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital Ramat Gan Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate C.","family":"Beinvogl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schvimer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Pathology, Sheba Medical Center, Tel Hashomer Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Department of Pathology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Matar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ben Tov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Pediatric Gastroenterology Institute Dana\u2010Dwek Children's Hospital, Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat Y.","family":"Feler","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Pediatric Gastroenterology Institute Dana\u2010Dwek Children's Hospital, Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurit","family":"Nachum","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital Ramat Gan Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Pathology, Rabin Medical Center Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Mayer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Pathology, Sheba Medical Center, Tel Hashomer Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batia","family":"Weiss","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Edmond and Lily Safra Children's Hospital Ramat Gan Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-2954","authenticated-orcid":false,"given":"Dror S.","family":"Shouval","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2292-18"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.09.033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9482-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003414"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0187-8"},{"issue":"8","key":"e_1_2_7_8_1","first-page":"100","article-title":"Autoimmune diseases in autoimmune atrophic gastritis","volume":"89","author":"Rodriguez\u2010Castro KI","year":"2018","journal-title":"Acta Bio\u2010Medica: Atenei Parmensis"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030530"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2000.00020.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1288758"},{"key":"e_1_2_7_12_1","volume-title":"Atrophic Gastritis","author":"Raza M","year":"2024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.07.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1157-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002278"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002547"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-016-0515-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2020.1718491"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"67","article-title":"The incidence of neoplasia in patients with autoimmune metaplastic atrophic gastritis: a renewed call for surveillance","volume":"32","author":"Mahmud N","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166266"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1010570"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.04.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202515"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.02.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12177"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90330-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.953574"},{"issue":"1","key":"e_1_2_7_28_1","first-page":"70","article-title":"Gastrointestinal neuroendocrine tumors in two children","volume":"53","author":"Koca T","year":"2016","journal-title":"Indian Pediatr"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000378"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvad082"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0345-RA"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12435"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3534"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.09.016"},{"key":"e_1_2_7_35_1","article-title":"Long\u2010term proton pump inhibitor (PPI) use and the development of gastric pre\u2010malignant lesions","volume":"201412","author":"Song H","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126548"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003862"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.619246"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1169-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.04.011"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i3.354"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80351-5"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.10.012"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5903"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.001"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.003"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.06.078"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S109123"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05101.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0353-8"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106666"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-1883"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:19Z","timestamp":1727280979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jpn3.12318"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12318","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]}}}