{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:46:54Z","timestamp":1773190014850,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study is to estimate rates and identify factors associated with erythema nodosum (EN) and pyoderma gangrenosum (PG) in pediatric patients with inflammatory bowel disease (IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study examined longitudinal visits of patients aged\u2009\u2264\u200921 years from the ImproveCareNow (ICN) registry. We evaluated the association of factors at the patient\u2010level (demographics and IBD diagnosis age) and visit\u2010level (IBD severity scores, markers and phenotypes, comorbidities, and treatment) with the presence of EN and PG, using longitudinal logistic regression models adjusted for time and within\u2010patient clustering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 285,913 visits from 32,497 patients aged\u2009\u2264\u200921 years from the ICN registry were analyzed. The occurrence of EN was 1.57% (95% confidence interval [95% CI]: 1.43%\u20131.71%) and the occurrence of PG was 0.90% (95% CI: 0.80%\u20131.00%). Co\u2010occurrence of EN and PG was reported in 0.30% (95% CI: 0.25%\u20130.37%) patients. Both EN and PG were associated (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) with worse intestinal disease, lower remission, higher inflammatory markers, and extraintestinal manifestations (EIMs) arthritis and uveitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EN and PG were associated with increased disease severity and other noncutaneous EIMs (arthritis and uveitis). A small subset of patients had developed both EN and PG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12370","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:05:54Z","timestamp":1725879954000},"page":"1009-1016","source":"Crossref","is-referenced-by-count":2,"title":["The association between erythema nodosum and pyoderma gangrenosum and pediatric inflammatory bowel disease"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-4574","authenticated-orcid":false,"given":"Miranda L.","family":"Yousif","sequence":"first","affiliation":[{"name":"College of Medicine, University of Arizona College of Medicine\u2010Phoenix Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ritchey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Mirea","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harper","family":"Price","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Arizona College of Medicine\u2010Phoenix Phoenix Arizona USA"},{"name":"Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"O'Haver","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Rudo\u2010Stern","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Arizona College of Medicine\u2010Phoenix Phoenix Arizona USA"},{"name":"Department of Gastroenterology, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Montoya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Gonzalez\u2010 Llanos","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Phoenix Children's Hospital Phoenix Arizona 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