{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:56:45Z","timestamp":1776704205370,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The no\u2010biopsy approach to diagnose celiac disease (CD), introduced in the 2012 European Society for Gastroenterology and Hepatology and Nutrition guidelines, requires an anti\u2010endomysial antibody (EMA) confirmatory serology test following a high\u2010positive immunoglobulin A anti\u2010tissue transglutaminase\u20102 (anti\u2010TG2) antibody \u226510 times the upper limit of normal (ULN). The aim of this retrospective study is to compare EMA positivity and high\u2010positive anti\u2010TG2 in patients who had their confirmatory test within 2 months of their first high\u2010positive\u00a0anti\u2010TG2 test. Among 933 patients who had high\u2010positive anti\u2010TG2 serology more than 10 times the ULN in their first sample, all had both high\u2010positive anti\u2010TG2 and positive EMA, most of them with very high EMA titers (99.6%) in their confirmatory test. In conclusion, we suggest that a repeated anti\u2010TG2 test can replace the EMA test as the confirmatory serology test for the confirmation of the diagnosis of CD in the no\u2010biopsy approach.<\/jats:p>","DOI":"10.1002\/jpn3.12383","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:44:08Z","timestamp":1728888248000},"page":"147-150","source":"Crossref","is-referenced-by-count":2,"title":["Endomysial antibodies or anti\u2010tissue transglutaminase type 2 IgA antibodies as a confirmatory test in children with celiac disease"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7626","authenticated-orcid":false,"given":"Amir","family":"Ben\u2010Tov","sequence":"first","affiliation":[{"name":"Maccabi Research &amp; Innovation Center, Maccabi Healthcare Services Tel Aviv Israel"},{"name":"Tel\u2010Aviv Sourasky Medical Center, Dana\u2010Dwek Children's Hospital, Pediatric Gastroenterology Institute Tel Aviv Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomer","family":"Achler","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Fayngor","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel\u2010Aviv University Tel Aviv Israel"},{"name":"Schneider Children's Medical Center, Institute of Pediatric Gastroenterology, Nutrition, and Liver Diseases Petah Tikva 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