{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:58:30Z","timestamp":1774655910097,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colonoscopy is performed for diagnostic and therapeutic purposes. The quality of colonoscopy depends on adequate bowel cleansing. However, there is no standardized protocol for bowel preparation in children. We conducted a systematic review and meta\u2010analysis of randomized controlled trials (RCTs) to estimate the effectiveness, safety, and tolerability profile of polyethylene glycol (PEG) compared with those of sodium picosulfate magnesium citrate (SPMC) in children. The primary sources of the reviewed studies were Scopus, PubMed, and Cochrane Library. The databases were systematically searched for RCTs comparing PEG 4000 to SPMC as a bowel cleansing solution. Six studies were included. The analysis showed that both PEG and SPMC are effective for bowel cleansing, while a split\u2010dose regimen may be preferable to a day\u2010before one. There were no differences between the two groups regarding adverse events (AEs) such as abdominal pain, nausea, vomiting, bloating, and anal discomfort. Additionally, preparation with SPMC was preferred in terms of acceptability and compliance. Still, the need to place a nasogastric tube was significantly lower in the SPMC group compared to the PEG group and in the split dose regimen compared to the day before. In conclusion, PEG and SPMC are equally effective in obtaining an adequate bowel cleansing with a comparable AE rate; moreover, split\u2010dose administration may be preferable to day\u2010before one in terms of effective bowel cleansing. However, SPMC preparation is more acceptable seems to result in higher compliance, and to reduce the use of a nasogastric tube, that we encounter daily in clinical practice, is perceived as a stressful experience for children and their families.<\/jats:p>","DOI":"10.1002\/jpn3.12388","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:44:29Z","timestamp":1728888269000},"page":"25-33","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness and safety of polyethylene\u2010glycol\u20104000 versus sodium picosulphate plus magnesium oxide and citric acid for bowel cleansing before colonoscopy in children: A systematic review with meta\u2010analysis"],"prefix":"10.1002","volume":"80","author":[{"given":"Silvia","family":"Furio","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Lucarini","sequence":"additional","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, General Surgery Unit Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Mennini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Felici","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Children's Hospital Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, General Surgery Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Neurosurgery Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-7758","authenticated-orcid":false,"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.07.058"},{"issue":"9","key":"e_1_2_7_3_1","article-title":"Polyethylene glycol versus senna for bowel preparation for colonoscopy in children: updated evidence by a systematic review and meta\u2010analysis","volume":"13","author":"Watanabe J","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.08.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001408"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03212.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000297"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000447"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000118"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.11.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326186"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.115"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-582"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1215333"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0131"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14481"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00371-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2013-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001562"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3230654"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002511"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02213-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02875-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.057"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:24:03Z","timestamp":1739258643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jpn3.12388"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12388","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]}}}