{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:49:16Z","timestamp":1776185356050,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report disease outcomes of pediatric Crohn's disease (CD) affecting the proximal small bowel (SB) and detected through video capsule endoscopy (VCE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective review of CD patients with VCE performed under age 18 between 2003 and 2017 and having received any biologics. We identified patients from our institutional registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eligible patients (<jats:italic>n<\/jats:italic>\u2009=\u2009118) had their first VCE performed after a median of 0.1 years after diagnostic endoscopies at a median age of 12.2 years. The proximal SB disease group (Paris classification L4b inclusive) comprised 70 patients with extensive SB lesions in 81% and deep ulcers in 79%. Patients with Paris L1\u20133 disease with no findings in VCE or disease restricted to the terminal ileum comprised the control group. At first VCE, levels of albumin (34 vs. 37\u2009g\/L) and hemoglobin (117 vs. 127\u2009g\/L) were lower in SB patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.02). After the first VCE, 68% were introduced to biologics, while 10% already received them. Follow\u2010up VCE was performed after a median of 2.4 years (SB group <jats:italic>n<\/jats:italic>\u2009=\u200942; controls <jats:italic>n<\/jats:italic>\u2009=\u200921). Proximal SB findings had disappeared in 40% of SB patients, and extensive lesions and deep ulcers had decreased to 26% and 29%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). In the control group, one had progressed to proximal disease. During the clinical follow\u2010up of a median of 4.7 years, one patient with SB underwent surgery for a jejunal stricture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proximal SB disease detected through capsule endoscopy abated in most patients with biological medication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12397","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T03:19:31Z","timestamp":1730517571000},"page":"124-132","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term follow\u2010up of children with Crohn's disease and small bowel mucosal lesions detected through video capsule endoscopy"],"prefix":"10.1002","volume":"80","author":[{"given":"Tytti","family":"Jaakkola","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit, Children's Hospital Helsinki University Hospital HUS Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-8891","authenticated-orcid":false,"given":"Laura","family":"Merras\u2010Salmio","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Children's Hospital Helsinki University Hospital HUS Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Nikkonen","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Children's Hospital Helsinki University Hospital HUS Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-8415","authenticated-orcid":false,"given":"Kaija\u2010Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Children's Hospital Helsinki University Hospital HUS Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa161"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.05.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2021.12.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.23008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.664722"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Small bowel imaging in Crohn's disease patients","volume":"31","author":"Gauci J","year":"2018","journal-title":"Ann 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