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The council of the Federation of International Societies for Pediatric Gastroenterology, Hepatology, and Nutrition (FISPGHAN) identified the topic of MASLD epidemiology, treatment, and prevention as a global priority issue to be addressed by an expert team, with the goal to describe feasible and evidence\u2010based actions that may contribute to reducing MASLD risk. The FISPGHAN member societies nominated experts in the field. The FISPGHAN council selected and appointed members of the expert team and a chair. The subtopics included in this manuscript were chosen through a consensus of the experts involved. We review the epidemiology, natural history, and screening and management. We further expand to relevant public health measures aimed at MASLD prevention, including identifying interventions that could reduce risk factors (environmental and iatrogenic), optimize maternal and newborn health, and support healthier lifestyles for older children and adolescents on a local, national, and international scale. While recognizing that various aspects of population health and public policy can shape MASLD risk, we also review what we can do on an individual level to support our patients to reduce the significant burden of this ever rising disease in pediatrics.<\/jats:p>","DOI":"10.1002\/jpn3.12399","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T09:33:12Z","timestamp":1735291992000},"page":"397-407","source":"Crossref","is-referenced-by-count":9,"title":["FISPGHAN statement on the global public health impact of metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1329","authenticated-orcid":false,"given":"Tania","family":"Mitsinikos","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Children's Hospital Los Angeles Los Angeles California USA"},{"name":"Department of Pediatrics University of Southern California Keck School of Medicine Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion M.","family":"Aw","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation National University of Singapore  Singapore"},{"name":"Department of Paediatrics National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bandsma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Godoy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hospital Clinico San Borja Arriaran Santiago Chile"},{"name":"Department of Pediatrics University of Chile Santiago 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