{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:27:49Z","timestamp":1791221269951,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric obesity, characterized by a body mass index (BMI) at or above the 95th percentile for age, affects a substantial number of children and adolescents worldwide. Metabolic dysfunction\u2010associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, represents a prominent hepatic manifestation of obesity and metabolic syndrome, emerging as the most prevalent hepatic disorder among pediatric patients and a significant contributor to liver transplantation in adults. The escalating prevalence of pediatric MASLD mirrors the alarming rise in childhood obesity rates over recent decades. While lifestyle modifications focusing on dietary changes and increased physical activity constitute the cornerstone of MASLD management, achieving and maintaining significant weight reduction remains challenging. Moreover, disease progression often persists despite standard\u2010of\u2010care interventions, warranting exploration into alternative therapeutic strategies. Pharmacological interventions, particularly, glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA), have shown promise in addressing pediatric obesity and its associated comorbidities, including MASLD. Recent studies have demonstrated the efficacy of GLP\u20101RA in inducing weight loss and improving liver enzyme levels, suggesting a potential role in halting disease progression, and reducing the risk of major adverse liver outcomes. This review provides a comprehensive overview of the current pharmacotherapy landscape for pediatric MASLD, with a focus on novel agents such as GLP\u20101RA. Furthermore, the manuscript proposes a practical algorithm to assist in integrating GLP\u20101RA into the clinical management of pediatric patients with obesity and MASLD. Despite promising results, further research is warranted to elucidate the long\u2010term efficacy and safety of GLP\u20101RA in pediatric populations.<\/jats:p>","DOI":"10.1002\/jpn3.12402","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T12:19:02Z","timestamp":1731327542000},"page":"14-24","source":"Crossref","is-referenced-by-count":20,"title":["Pharmacological management of pediatric metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"80","author":[{"given":"Rasha Abi Radi","family":"Abou Jaoudeh","sequence":"first","affiliation":[{"name":"Division of Pediatrics and Adolescent Medicine Cleveland Clinic Children's Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipp","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Diego La Jolla California USA"},{"name":"Division of Pediatric 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Fawaz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Yale New Haven Children's Hospital New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Aqul","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition University of Texas Southwester Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9425","authenticated-orcid":false,"given":"Sara","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition, Mayo Clinic Rochester Minnesota 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