{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:22:43Z","timestamp":1792693363128,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Upadacitinib, an oral Janus kinase inhibitor (JAKi), is approved for inflammatory bowel disease (IBD) in adults. As on\u2010label use will face significant delay in pediatrics, a real\u2010world understanding of safety and efficacy in children is critical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center retrospective cohort of pediatric subjects (ages 9\u201320 years) with a diagnosis of IBD initiated on upadacitinib. The primary outcome was clinical response following induction (decrease of \u226520 points in the Pediatric Ulcerative Colitis Activity Index [PUCAI] or \u226512.5 points for the Pediatric Crohn's Disease Activity Index [PCDAI]). Secondary outcomes included steroid\u2010free clinical remission (SF\u2010CR) following induction and at Week 24 (PUCAI or PCDAI \u226410), post\u2010induction mucosal response and remission (Mayo for ulcerative colitis [UC]\/IBD\u2010unclassified [IBD\u2010U] and simple\u2010endoscopic scoring for CD), and improvement in calprotectin and C\u2010reactive protein (CRP) post\u2010induction. Monitoring for adverse events was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty subjects (40% female with a median age of 16.3 years; 3 CD, 13 UC, 4 IBD\u2010U) were initiated on upadacitinib. Clinical response at Week 8 (UC\/IBD\u2010U) and Week 12 (CD), was achieved in 90% (18\/20). SF\u2010CR was seen in 75% (16\/20) following induction and maintained in 65% (11\/17) reaching Week 24 of therapy. In subjects with UC\/IBD\u2010U (17), PUCAI was significantly improved at Weeks 8 and 24. Calprotectin post\u2010induction showed a significant downtrend, whereas CRP did not. Endoscopic response was noted in seven of the eight cases, with three achieving endoscopic remission. One patient underwent subtotal colectomy after 2 weeks of upadacitinib induction. Another patient stopped therapy following the creation of a diverting ileostomy secondary to rectal perforation experienced following manual dilation of a rectal stricture. No new safety signals were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therapeutic options for children with IBD remain limited. In cases refractory to approved agents, our experience suggests that upadacitinib is effective with no new safety signals in a small subset of patients with IBD (ages 9\u201320 years) treated at a children's hospital.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12408","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:04:54Z","timestamp":1731564294000},"page":"133-140","source":"Crossref","is-referenced-by-count":23,"title":["Upadacitinib is associated with clinical response and steroid\u2010free remission for children and adolescents with inflammatory bowel disease"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-0660","authenticated-orcid":false,"given":"Joseph","family":"Runde","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hirst","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lebowitz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Chen","sequence":"additional","affiliation":[{"name":"Stanley Manne Children's Research Institute, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Strople","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00360-x"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"619","article-title":"Prevalence of inflammatory bowel disease in pediatric and adult populations: recent estimates from large national databases in the United States, 2007\u20132016","volume":"26","author":"Ye Y","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.07.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.282"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318440"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1707500"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212728"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00581-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00377-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.038"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab140"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003190"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003616"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","unstructured":"LedderO DolingerM DubinskyMC et al.Tofacitinib in pediatric ulcerative colitis: a retrospective multicenter experience.Inflamm Bowel Dis. 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