{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:10:40Z","timestamp":1787605840083,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We sought to prospectively evaluate whether food protein\u2010induced allergic proctocolitis (FPIAP) during infancy is associated with increased constipation later in childhood. Using the Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) cohort, we reviewed charts of children with prospective parent\u2010reported constipation after age 3 to confirm the diagnosis of constipation. A diagnosis of FPIAP was based on pediatrician diagnosis and required guaiac\u2010positive or grossly bloody stools, as previously published. Three hundred and seventy\u2010five subjects had sufficient data for these analyses. Subjects with FPIAP had more than two times the odds of developing constipation after age 3 compared to subjects without (odds ratio [OR]: 2.62, 95% confidence interval [CI]: [1.42\u20134.74], <jats:italic>p<\/jats:italic>\u2009=\u20090.002). The use of stimulant laxatives was also higher in children with FPIAP (OR: 4.68, 95% CI: [1.47\u201316.04], <jats:italic>p<\/jats:italic>\u2009=\u20090.01). FPIAP was prospectively associated with the later development of constipation after age 3. This may suggest shared underlying pathogenesis, resultant heightened visceral hypersensitivity, and\/or intestinal dysbiosis, all warranting further study.<\/jats:p>","DOI":"10.1002\/jpn3.12410","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T09:54:54Z","timestamp":1732528494000},"page":"108-112","source":"Crossref","is-referenced-by-count":4,"title":["Prospective association between food protein\u2010induced allergic proctocolitis in infancy and constipation after age 3"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7431-6310","authenticated-orcid":false,"given":"Michael","family":"Marget","sequence":"first","affiliation":[{"name":"Food Allergy Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, Hepatology, and Nutrition Connecticut Children's Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Food Allergy Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne G.","family":"Shreffler","sequence":"additional","affiliation":[{"name":"Food Allergy Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Food Allergy Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4322-9564","authenticated-orcid":false,"given":"Victoria M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Food Allergy Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.12.029"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100471"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0202"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v51i4.872"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01322-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181e85b55"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-019-0690-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0537"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/131215"},{"key":"e_1_2_7_12_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2020.https:\/\/www.R-project.org\/"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02885-9"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"91","article-title":"Effect of cow's\u2010milk\u2010free diet on chronic constipation in children; a randomized clinical trial","volume":"12","author":"Mohammadi Bourkheili A","year":"2021","journal-title":"Casp J Intern Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091785"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.09.010"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:22:48Z","timestamp":1739258568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jpn3.12410"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12410","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]}}}