{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:52:36Z","timestamp":1788357156160,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Portal hypertension, a common sequela of chronic liver disease, is complicated by variceal hemorrhage, one of its most serious complications. Evidence\u2010based approaches to managing variceal hemorrhage are limited by the scarcity of data related to this rare entity. Multicenter international registries are increasingly utilized to garner critical information about rare diseases. The International Multicenter Pediatric Portal Hypertension Registry (IMPPHR) was developed to acquire pediatric data about the mortality of first variceal hemorrhage and approaches to primary and second prophylaxis of variceal hemorrhage with a goal of improving outcomes in children with portal hypertension. IMPPHR evolved from pediatric portal hypertension symposia at the Baveno V and VI meetings in 2010 and 2015, with a formal executive committee initiating the development of IMPPHR in 2019. The registry opened in 2020, with data closure in 2024, including information from 44 centers and &gt;700 subjects. The complexities and approaches to developing IMPPHR are described.<\/jats:p>","DOI":"10.1002\/jpn3.12415","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:44:34Z","timestamp":1731923074000},"page":"197-202","source":"Crossref","is-referenced-by-count":3,"title":["Considerations in the development of the International Multicenter Pediatric Portal Hypertension Registry"],"prefix":"10.1002","volume":"80","author":[{"given":"Tassos","family":"Grammatikopoulos","sequence":"first","affiliation":[{"name":"Paediatric Liver, GI &amp; Nutrition Centre and Mowat Labs King's College Hospital NHS Trust London UK"},{"name":"School of Immunology &amp; Microbial Sciences, Institute of Liver Studies King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Molleston","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine\/Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas\u2014UFMG, Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oanez","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Hepatologie et Transplantation Hepatique Pediatriques, Centre de reference de l'atresie des voies biliaires et des cholestases genetiques, FSMR FILFOIE, ERN RARE LIVER Hopital Bicetre, AP\u2010HP, Universite Paris\u2010Saclay, Hepatinov, Inserm U Le Kremlin\u2010Bicetre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Superina","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Franchis","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Tutan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ling","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-0949","authenticated-orcid":false,"given":"Benjamin L.","family":"Shneider","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2021.104245"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2012.01652.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28153"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.026"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29204"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32761"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-023-01471-0"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.12415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:22:18Z","timestamp":1739258538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.12415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jpn3.12415"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.12415","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}