{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:42:12Z","timestamp":1765370532678,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Nancy Histological Index (NHI) is used to score histologic disease activity in patients with ulcerative colitis (UC). Our goal was to assess the utility of NHI at diagnosis in predicting clinical outcomes in pediatric patients with UC, in comparison to clinical and endoscopic scores. We retrospectively reviewed data at diagnosis of 106 children with UC (59 [55.7%] females; median age 14.4 [11.2\u201315.9] years, median Pediatric Ulcerative Colitis Activity Index [PUCAI] 35 [25\u201355]). During a follow\u2010up of 116 (55\u2013171) weeks, 33 patients (31.1%) required azathioprine therapy, and 32 (30.2%) were escalated to anti\u2010tumor necrosis factor alpha (anti\u2010TNFa). The PUCAI and Mayo endoscopic scores at diagnosis were significantly associated with escalation to anti\u2010TNFa (<jats:italic>p<\/jats:italic>\u2009=\u20090.036 and <jats:italic>p<\/jats:italic>\u2009=\u20090.02, respectively), but not with initiation of azathioprine or subsequent acute severe colitis (ASC) events. However, the NHI was not associated with subsequent immunomodulators or anti\u2010TNFa therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.42 and <jats:italic>p<\/jats:italic>\u2009=\u20090.78, respectively), nor with future ASC events (<jats:italic>p<\/jats:italic>\u2009=\u20090.70). In conclusion, the NHI failed to predict clinical outcomes in newly diagnosed pediatric patients with UC.<\/jats:p>","DOI":"10.1002\/jpn3.12416","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T07:15:00Z","timestamp":1731654900000},"page":"141-146","source":"Crossref","is-referenced-by-count":2,"title":["The Nancy Histopathological Index has limited value in predicting clinical outcomes in newly diagnosed pediatric patients with ulcerative colitis"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-7319","authenticated-orcid":false,"given":"Yaniv","family":"Faingelernt","sequence":"first","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Birger","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Institute of Pathology Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0083-9443","authenticated-orcid":false,"given":"Eyal","family":"Cohen\u2010Sela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manar","family":"Matar","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-2954","authenticated-orcid":false,"given":"Dror S.","family":"Shouval","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa110"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310187"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad087"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312722"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003753"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001400"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy113"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32592-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad111"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001941"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.09.018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.09.046"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.043"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235551"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003746"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001009"}],"container-title":["Journal 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