{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:56:24Z","timestamp":1783850184791,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Graft\u2010versus\u2010host disease (GVHD) commonly affects the gastrointestinal (GI) tract among children who undergo hematopoietic stem cell transplantation (HSCT). Studies concerning GI\u2010acute GVHD (aGVHD) in developing countries are limited. Therefore, our aims were (1) to demonstrate clinical characteristics, endoscopic and histopathological findings in children with GI\u2010aGVHD post\u2010HSCT and (2) to compare features, risk factors, and clinical outcomes of children with GI\u2010aGVHD versus non GI\u2010aGVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010center study was conducted on patients receiving the first successful HSCT aged &lt;20 years old between January 2011 and December 2020. The patients were divided into groups with GI\u2010aGVHD (clinically or endoscopy\u2010histopathologically diagnosed) and without GI\u2010aGVHD. Various aforementioned data were recorded to compare the risk factors and clinical outcomes of children with and without GI\u2010aGVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 246 children post\u2010HSCT, we identified 42 cases (17%) with GI\u2010aGVHD (32 cases with the clinical diagnosis and 10 cases with endoscopy\u2010histopathology confirmed diagnosis) and 204 patients without GI\u2010aGVHD. When compared with children without GI\u2010aGVHD, the GI\u2010aGVHD group had higher rates of hypovolemic shock, renal failure, more extended hospital stays, and deaths (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The GI\u2010aGVHD group also had a higher proportion of cases with nonhematologic malignancy (odds ratio [OR]\u2009=\u20092.34, 95% confidence interval [CI]\u2009=\u20091.01\u20135.41, <jats:italic>p<\/jats:italic>\u2009=\u20090.047) and cytomegalovirus (CMV) reactivation before the GI\u2010aGVHD episode (OR\u2009=\u20092.22, 95% CI\u2009=\u20091.09\u20134.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GI\u2010aGVHD after HSCT leads to increased morbidity and death. Underlying nonhematologic malignancy and history of CMV reactivation are associated with GI\u2010aGVHD. Direct links between the aforementioned factors and the development of GI\u2010aGVHD merit future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12425","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:54:27Z","timestamp":1733316867000},"page":"271-281","source":"Crossref","is-referenced-by-count":4,"title":["Features of gastrointestinal acute graft\u2010versus\u2010host disease in children undergoing hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"80","author":[{"given":"Kritiya","family":"Rattanaseksan","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usanarat","family":"Anurathapan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-8805","authenticated-orcid":false,"given":"Pornthep","family":"Tanpowpong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.433"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9451950"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204914"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.03.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.016"},{"key":"e_1_2_9_7_1","first-page":"95","article-title":"Graft\u2010versus\u2010host disease following bone marrow transplantation: clinical feature and diagnosis","volume":"39","author":"Kikuta A","year":"1993","journal-title":"Fukushima J Med Sci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1194891"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04021-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2023.03.341"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.126"},{"key":"e_1_2_9_12_1","unstructured":"MargolisRAPaD. 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