{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:55:06Z","timestamp":1787230506536,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our study was to assess the effectiveness and side\u2010effect profile of a combination of azithromycin and metronidazole (CD AZCRO) as alternative induction therapy for 8 weeks in mild to moderately active paediatric Crohn's disease (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study (November 2012 to July 2023) of a regional paediatric inflammatory bowel disease service. Disease activity, faecal calprotectin (FC), C\u2010reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematological parameters and albumin were collected at baseline, 8 and 16 weeks. At Week 8, patients were divided based on (paediatric Crohn's disease activity index) score and inflammatory markers (blood and stool) into: Group 1 clinical remission and Group 2 non\u2010remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 patients were initially identified of whom 44 were included in the intention\u2010to\u2010treat analysis. After 8 weeks, the overall remission rate was 64%. Of the 38 patients who completed the CD AZCRO course, 28 patients (74%) entered remission (Group 1) and 10 (26%) did not (Group 2). At baseline a shorter disease duration, low weight <jats:italic>z<\/jats:italic> score and higher inflammatory burden (ESR, platelets and FC levels) were observed in Group 2. After 8 weeks, Group 1 showed improved CRP levels and higher albumin and haemoglobin levels than Group 2. Median FC declined significantly from 650\u2009mcg\/g at baseline to 190\u2009mcg\/g at Week 8 in Group 1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At 16 weeks, 23\/28 patients (82%) continued in clinical remission. Nausea and vomiting were reported in 4\/44 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our real\u2010world data demonstrate that CD AZCRO represents an alternative induction therapy for mild to moderate paediatric CD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12430","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T10:23:54Z","timestamp":1733739834000},"page":"300-307","source":"Crossref","is-referenced-by-count":3,"title":["A decade of real\u2010world clinical experience with 8\u2010week azithromycin\u2013metronidazole combined therapy in paediatric Crohn's disease"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-3237","authenticated-orcid":false,"given":"Maria Teresa","family":"Fioretti","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gianolio","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind M.","family":"Rabone","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"},{"name":"Child Life and Health University of Edinburgh, Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"},{"name":"Child Life and Health University of Edinburgh, Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-4926","authenticated-orcid":false,"given":"Richard K.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People Edinburgh UK"},{"name":"Child Life and Health University of Edinburgh, Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i41.5862"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.282"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1982"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002842"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.01.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00291.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i5.648"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68265-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000225330.38119.c7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq345"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.32130"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz130"},{"key":"e_1_2_8_16_1","article-title":"Antibiotics 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