{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:08:31Z","timestamp":1774094911718,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. When a child is diagnosed with both PSC and inflammatory bowel disease (IBD), evidence\u2010based information on counseling families and risk management of developing cholangiocarcinoma is limited. In this case series (PubMed\/collaborators), we included patients with PSC\u2010IBD who developed cholangiocarcinoma and contacted authors to determine an event curve specifying the time between the second diagnosis (IBD or PSC) and a diagnosis of cholangiocarcinoma. Review of <jats:italic>n<\/jats:italic>\u2009=\u2009175 studies resulted in a cohort of <jats:italic>n\u2009<\/jats:italic>=\u200921 patients with pediatric\u2010onset PSC\u2010IBD\u2010cholangiocarcinoma. The median time to development of cholangiocarcinoma was 6.95 years from the second diagnosis. Despite the small number, 38% of cholangiocarcinoma developed within the first 2 years, and 47% of patients developed cholangiocarcinoma in the transition period to adult care (age 14\u201325). Our findings highlight the importance of screening that extends over the so\u2010called transition period from pediatric to adult care.<\/jats:p>","DOI":"10.1002\/jpn3.12443","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:27:47Z","timestamp":1734694067000},"page":"450-454","source":"Crossref","is-referenced-by-count":4,"title":["Determining the time to cholangiocarcinoma in pediatric\u2010onset PSC\u2010IBD"],"prefix":"10.1002","volume":"80","author":[{"given":"Batul","family":"Kaj\u2010Carbaidwala","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition MassGeneral Hospital for Children Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Fevery","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospital Gasthuisberg Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"Adler","sequence":"additional","affiliation":[{"name":"Porter Adventist Hospital Centura Health Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Bergquist","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Upper GI Disease Karolinska University Hospital and Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lissy","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Erasmus MC\u2010Sophia Children's Hospital Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Deneau","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Gower\u2010Rousseau","sequence":"additional","affiliation":[{"name":"Research and Public Health Unit, Robert Debr\u00e9 Hospital Reims University Hospital Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger W.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate D.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit, Nuffield Department of Medicine University of Oxford Oxford UK"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A. 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