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This was initially delivered in the form of homemade BTF (HBTF) and led to the development of commercial food\u2010based formula (CFBF). The safety and clinical outcome data for CFBF are limited. From our systematic review of the clinical benefits of pediatric CFBF, we found that families are very satisfied with CFBF despite the paucity of research. Most included studies evaluated both HBTF and CFBF, with only a few evaluating CFBF alone. The limited data suggests that CFBF may improve upper and lower GI symptoms such as nausea, vomiting, retching, constipation, and diarrhea; however, the effects of CFBF on growth have been mixed.<\/jats:p>","DOI":"10.1002\/jpn3.12450","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T09:39:26Z","timestamp":1735292366000},"page":"501-509","source":"Crossref","is-referenced-by-count":7,"title":["Clinical effects of pediatric commercial food\u2010based formulas: A systematic review"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-4498","authenticated-orcid":false,"given":"Judy\u2010April","family":"Murayi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Nationwide Children's Hospital Columbus Ohio 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