{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:31:01Z","timestamp":1790346661877,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine if after 2 years of consuming a gluten\u2010free diet post celiac disease diagnosis, pediatric patients who were overweight or obese at diagnosis are less likely to normalize celiac disease serologies as compared with those who were normal weight or underweight at diagnosis. Secondary aims include characterizing how initial symptoms at presentation predict body mass index (BMI) change and serology improvement over the first 2 years of being on a gluten\u2010free diet following diagnosis of celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed that included all biopsy\u2010proven celiac disease patients followed at Stony Brook Children's Hospital's Celiac Disease Center diagnosed between the years 2007\u20132022. This included all patients between 2 and 18 years of age who had their BMI documented at the time of diagnosis and at least one additional BMI documented 2 years\u2009\u00b1\u200912 months after starting the gluten\u2010free diet. Data collected included BMI and celiac serology at and 2 years\u2009\u00b1\u200912 months after diagnosis as well as symptoms, sex, age, race, and ethnicity at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The charts of 229 pediatric patients with Celiac Disease were reviewed. Out of 229 patients, 89 had BMIs and celiac serologies available at diagnosis and at 2\u2010year follow\u2010up which were included. Based on multivariable logistic regression model, patients with overweight or obese BMI at baseline were not less likely (odds ratio [OR]\u2009=\u20090.97, 95% confidence interval [CI]: 0.29\u20133.27) to normalize their celiac serologies at 2\u2010year follow\u2010up visit as compared with patients who were normal weight or underweight at baseline. Patients with GI symptoms at diagnosis were more likely (OR\u2009=\u20093.86, 95% CI: 1.29, 11.54) to normalize their celiac serologies at 2\u2010year follow\u2010up visit as compared with patients without GI symptoms at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rate of normalization of celiac serologies 2 years after initiating a gluten\u2010free diet showed no difference between the overweight or obese and normal weight or underweight pediatric populations. However, patients with GI symptoms at diagnosis were more likely to normalize their celiac serologies by 2\u2010year follow\u2010up visit, suggesting they may be more likely to comply with the gluten\u2010free diet.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12459","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T11:14:53Z","timestamp":1735902893000},"page":"455-461","source":"Crossref","is-referenced-by-count":2,"title":["Effect of BMI and symptoms at celiac disease diagnosis on serology normalization after 2 years of a gluten\u2010free diet in children"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-4473","authenticated-orcid":false,"given":"Ezra","family":"Hornik","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine Stony Brook University Stony Brook USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Imdad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology, and Nutrition, Stony Brook Children's Hospital Stony Brook USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology, and Nutrition, Stony Brook Children's Hospital Stony Brook USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting Core Office of Scientific Affairs, Stony Brook School of Medicine Stony Brook USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Small\u2010Harary","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology, and Nutrition, Stony Brook Children's Hospital Stony Brook USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03826-w"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6010207"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05001.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.169"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.161"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182276d5e"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2005.tb00917.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04535-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.200"},{"key":"e_1_2_7_12_1","unstructured":"Growth Charts\u20102000 CDC Growth Charts\u2010United States. 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