{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:52:52Z","timestamp":1782978772866,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fecal calprotectin (FC) is a marker commonly used in the diagnosis and follow\u2010up of inflammatory bowel diseases (IBD). However, other gastrointestinal conditions, like <jats:italic>H. pylori<\/jats:italic> (HP) infection, can result in increased neutrophil activity as well. We set out to assess the impact of HP infection on FC and downstream gastrointestinal care via a retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we collected data from two institutions in Brooklyn, NY, in a high immigrant density community. We reviewed data from patients who underwent esophagogastroduodenoscopy (EGD) between January 2017 and October 2022. Patients aged 6\u201318 years old with an FC level 6 months prior to EGD and HP testing were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 129 patients, 37 (28.7%) tested positive for HP infection. The mean FC level was significantly elevated in HP\u2010positive patients (241.2, confidence interval [CI]: 161.0\u2013321.3) as compared with HP\u2010negative patients (88.1, CI: 59.1\u2013117.0) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Patients with higher FC levels were also more likely to undergo colonoscopies (<jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>HP infection is associated with increased calprotectin, and calprotectin increases in HP patients are associated with an increased risk of colonoscopy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpn3.12464","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T12:35:56Z","timestamp":1737376556000},"page":"617-622","source":"Crossref","is-referenced-by-count":3,"title":["<i>Helicobacter pylori<\/i> infection is associated with significant elevations to fecal calprotectin, systemic inflammatory markers"],"prefix":"10.1002","volume":"80","author":[{"given":"Priscila","family":"Villalba\u2010Davila","sequence":"first","affiliation":[{"name":"Department of Pediatrics SUNY Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Aronson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Maimonides Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Maimonides Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SUNY Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology SUNY Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Pathology Maimonides Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology Maimonides Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-1363","authenticated-orcid":false,"given":"Thomas","family":"Wallach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology SUNY Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"77","article-title":"Faecal calprotectin","volume":"39","author":"Pathirana WGW","year":"2018","journal-title":"Clin Biochem 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